Figure 6

Decrease in TrkB-ErbB4 interaction in the prefrontal cortex of schizophrenia subjects. (A) Immunoprecipitation (IP) with the anti-TrkB antibody followed by blotting with the anti-ErbB4 or anti-TrkB was performed in prefrontal cortex samples from control (N = 15) and schizophrenia (N = 15) subjects. Representative immunoblots and quantification of normalized ErbB4 are shown. (B) Decrease in TrkB protein levels in the prefrontal cortex of schizophrenia subjects as determined by western blotting with anti-TrkB antibody. The upper panel shows a representative autoradiogram of TrkB and β-tubulin, and the lower panel represents normalized TrkB values. Data represent mean ± SEM. (N = 15 for schizophrenia and N = 15 for control subjects). *P < 0.05 vs controls.