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Figure 1 | Cell Communication and Signaling

Figure 1

From: miRNAs affect the development of hepatocellular carcinoma via dysregulation of their biogenesis and expression

Figure 1

Schematic representation of the biogenesis pathway of microRNAs and the aberrant expression of key enzymes involved in this pathway in HCC. First, miRNAs are transcribed by RNA pol II/III from the miRNA coding gene to pri-miRNAs, and soon afterwards microprocessor complex recognizes pri-miRNA to generate pre-miRNA. XPO-5 with its cofactor RAN-GTP mediates the nuclear export of pre-miRNA. Finally, the RLC loading complex assists in the binding of mature miRNA to RISC to mediate gene silencing. However, in HCC, the expression of some key enzymes involved in this pathway appears to be aberrant, and this aberrant expression results in an abnormal microRNA biogenesis pathway (shown in A/B/C/D/E).

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Cell Communication and Signaling

ISSN: 1478-811X