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Figure 4 | Cell Communication and Signaling

Figure 4

From: Integration of proteomic and transcriptomic profiles identifies a novel PDGF-MYC network in human smooth muscle cells

Figure 4

Integration and comparison of DEGs and DEPs. (A) Venn diagram depicts overlap between DEGs (n = 1695) and DEPs (n = 241), leading to 40 common gene and protein species. (B) Differential expression of these 40 molecules was significantly correlated (p ≤ 0.01, Spearman rank correlation test). (C) Heatmap shows the differential expression pattern of 22 common genes/proteins in response to 4 h and 24 h PDGF-BB treatment (HPCAL1, SERPINE1 and KIF11 are represented at both time points). (D) Enriched biological processes common to DEGs and DEPs. (E) MYC-centric network describing putative regulation of common gene/protein signature. The node and node border color represent expression changes of mRNA and protein, with the color showing increased (red) and decreased (green) expression. (F) The 22 common mRNA and protein species were classified functionally into angiogenesis chemotaxis, cell migration, or proliferation.

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