Figure 3
From: Macroscopic law of conservation revealed in the population dynamics of Toll-like receptor signaling
Deterministic information conserved response of average cell signaling. A) Temporal concentration response profiles of linear-chain reaction network for pulse perturbation of specie X 1 (see maintext and [14]). The units are arbitrary, scaled by rate coefficients. u1 represents reaction profile for X 1 , u2 for X 2 and so on. B) Temporal activation profiles of various EGFR signaling effectors: key proteins involved in receptor internalization and endosomal trafficking (upper panel) and proteins from the Ras-MAP kinase pathways (lower panel). C) The concept of signaling flux redistribution or SFR. Simulation profiles of proinflammatory molecules in wildtype (blue), MyD88 KO (red) and MyD88 overexpression (green). D) Experimental enhancement of TRAM-dependent molecules Cxcl10 and Ifit2 in MyD88 KO through SFR. Blue lines indicate WT and red dotted lines indicate MyD88 KO. A adopted from [14], B from [17] and C, D from [18].