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Figure 3 | Cell Communication and Signaling

Figure 3

From: Pro- and anti-apoptotic CD95 signaling in T cells

Figure 3

Costimulation with low doses of CD95 agonists increases primary T cell activation. CD95 coligation enhances MAPK and NF-κB activation in TCR-triggered cells and results in accelerated induction of activation markers, cell cycle regulatory proteins, cytokine secretion and cell cycle progression. The incomplete cleavage of caspase-3 into p20 fragments (possibly achieved by an interaction with XIAP) seems to be characteristic for non-apoptotic caspase activation and becomes more prominent upon CD95 costimulation. In line with the observed upregulation of anti-apoptotic proteins including cFLIPR/S and Bcl-XL in the presence of low dose CD95 agonists, CD95/TCR-stimulated cells display a partial apoptosis resistance.

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