Figure 2

Dose-dependent effects of CD95 coligation on primary T cell activation. CD95 is capable of transducing non-apoptotic costimulatory signals in TCR/CD3-stimulated naïve T cells. Interestingly, the outcome of CD95 costimulation depends on the dose of agonist. Whereas high concentrations of CD95 agonists silence T cells, low doses augment TCR-induced activation and proliferation. Thus CD95 can act as a silencer or enhancer of primary T cell activation (see text for detail).