Table 1 Proteins identified in enriched secretory lysosomes from activated T cells.

100 kDa coactivator

14-3-3 protein beta

14-3-3 protein epsilon

14-3-3 protein zeta/delta

2',3'-cyclic-nucleotide 3'-phosphodiesterase

26S protease regulatory subunit 6A

26S proteasome non-ATPase regulatory subunit 2

3-phosphoglycerate dehydrogenase

acetyl-CoA acetyltransferase, cytosolic

ACTB protein

actin related protein 2 isoform b

actin related protein 2/3 complex subunit 1B

actin related protein 2/3 complex subunit 2

actin related protein 2/3 complex subunit 3

actin related protein 2/3 complex subunit 4

actin related protein 2/3 complex subunit 5-like

actin, alpha, cardiac muscle

actin, gamma 1 propeptide

actinin, alpha 4

acylamino acid-releasing enzyme

acyl-CoA synthetase long-chain family member 4 isoform 2

adenine phosphoribosyltransferase isoform b

adenosine deaminase

adenylosuccinate lyase

adenylosuccinate synthetase

adenylyl cyclase-associated protein variant

aflatoxin aldehyde reductase AFAR

aging-associated gene 12

alanyl-tRNA synthetase

alcohol dehydrogenase class-3

aldo-keto reductase family 1, member A1

aldolase A

aldose 1-epimerase (BLOCK25)

aldose reductase

alkyldihydroxyacetonephosphate synthase, peroxisomal

alpha-tubulin

annexin A1

annexin A11

annexin A2

annexin A4

annexin A5

annexin A6

annexin A7 isoform 2

ARP3 actin-related protein 3 homolog

ARTS-1

aryl hydrocarbon receptor interacting protein

asparaginyl-tRNA synthetase

aspartate aminotransferase

ATP citrate lyase

ATP synthase, alpha subunit precursor

ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2

axin interactor, dorsalization associated protein

beta adrenergic receptor kinase 1

bifunctional purine biosynthesis protein PURH

bleomycin hydrolase

BolA-like protein 2

calcium binding protein 39

CALM3 protein

calreticulin precursor variant

carboxyl terminal LIM domain protein

catalase

cathepsin B

cathepsin D preproprotein

cathepsin H

cathepsin S

Cbr1 In Complex With Hydroxy-Pp

Cdc42ACK GTPASE

centaurin beta1

chaperonin (HSP60)

chaperonin containing TCP1, subunit 2β

chaperonin containing TCP1, subunit 7η

chaperonin containing TCP1, subunti 5ε

chaperonin containing TCP1, subunti 8τ

chaperonin containing TCP1, subunti 8τ

chromatin modifying protein 4B

chromosome 20 open reading frame 3 (BSCv)

chromosome 9 open reading frame 19

N2 protein

coactosin-like protein

cofilin 1

copine I

copine III

coronin 7

coronin, actin binding protein, 1A

coronin, actin binding protein, 1C

c-src tyrosine kinase

cyclophilin A

cyclophilin B

cystatin B

cysteine and glycine-rich protein 1

cytoskeleton associated protein

cytosolic malate dehydrogenase

DCHT2 Serine/threonine-protein kinase OSR1

destrin isoform a

differentially expressed in FDCP 6 homolog (mouse), isoform CRA_b

dihydropyrimidinase-like 2

dimethylarginine dimethylaminohydrolase 2

dipeptidyl peptidase 4

DJ-1 protein

DnaJ (Hsp40) homolog, subfamily A, member 1, isoform CRA_d

DnaJ (Hsp40) homolog, subfamily B, member 11 precursor

docking protein 2

dynamin 2 isoform 1

echinoderm microtubule associated protein like 2 variant

EF-hand domain family, member D2

EH-domain containing 1

Ena-VASP-like protein

ENC-1AS aka Beta-hexosaminidase subunit beta

endoplasmic reticulum protein 29 isoform 1 precursor

enolase 1 variant

ERAP2 protein

ERBB2IP protein

ERO1L

esterase D/formylglutathione hydrolase

eukaryotic translation elongation factor 1 alpha 1

eukaryotic translation elongation factor 1 gamma, isoform CRA_d

eukaryotic translation elongation factor 2

eukaryotic translation initiation factor 4A

eukaryotic translation initiation factor 5A

extended-synaptotagmin-1 KIAA0747 protein

ezrin

F-actin capping protein alpha-1 subunit

F-actin capping protein alpha-1 subunit variant

F-actin capping protein alpha-2 subunit

F-actin capping protein beta subunit

farnesyl pyrophosphate synthetase

FK506 binding protein 1A

flotillin 1

formin-binding protein 1

fructose-bisphosphate aldolase C

fumarate hydratase, mitochondrial

FYN-binding protein

G protein beta subunit

galectin-1

galectin-3

gamma-enolase

gamma-glutamyl hydrolase

GDP-mannose pyrophosphorylase A

gelsolin-like capping protein isoform 9

GIPC1 protein

glia maturation factor gamma

glucosamine-6-phosphate deaminase 1

glucose-6-phosphate dehydrogenase isoform b

glucosidase II subunit beta

glucosidase, alpha; neutral AB, isoform CRA_a

glutamate carboxypeptidase

glutamate Dehydrogenase-Apo Form

glutaredoxin 3

glutathione S-transferase P1

glutathione synthetase

glutathione-S-transferase kappa 1

glutathione-S-transferase omega 1

glyceraldehyde-3-phosphate dehydrogenase

glycyl-tRNA synthetase

glyoxalase domain containing 4

GNAS complex locus isoform f

GNB1 protein

granzyme A

GRAP2 protein

GRB2 protein

GTP-binding nuclear protein Ran

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, isoform CRA_c

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, isoform CRA_d

guanine nucleotide-binding protein G(k) subunit alpha

guanine nucleotide-binding protein subunit alpha-13

haloacid dehalogenase-like hydrolase domain containing 2

heat shock 70kDa protein 1A

heat shock 70kDa protein 5

heat shock 70kDa protein 8 isoform 1

heat shock 70kDa protein 8 isoform 1

heat shock protein 70

heat shock protein HSP 90-alpha

heat shock protein HSP 90-beta

hematopoietic cell-specific Lyn substrate 1

HEXA protein

hexose-6-phosphate dehydrogenase

HIP-55

histidine triad nucleotide binding protein 1

histocompatibility (minor) HA-1

hypothetical protein

hypothetical protein LOC79624

hypoxia up-regulated protein 1

importin subunit beta-1

integrin beta-2

interleukin-16

isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_b

isocitrate dehydrogenase 2 (NADP+), mitochondrial, isoform CRA_b

kinase/transmembrane domain fusion protein

laminin-binding protein

leucine aminopeptidase 3

leucine rich repeat containing 57

leucine-rich repeat and calponin homology domain-containing protein 5

leucocyte antigen CD97

leukocyte-derived arginine aminopeptidase long form variant

leukotriene A4 hydrolase

LIM and SH3 domain protein 1

LIM domain-containing protein 2

lin 7 homolog c

L-lactate dehydrogenase

L-lactate dehydrogenase B chain

L-plastin

L-plastin variant

LPXN protein

lymphocyte cytosolic protein 2

lymphocyte-specific protein 1

lysosomal acid alpha-mannosidase

M2-type pyruvate kinase

Macrophage Migration Inhibitory Factor (Mif) With Hydroxphenylpyruvate

MAGUK p55 subfamily member 7

methylenetetrahydrofolate dehydrogenase 1

methylthioadenosine phosphorylase

MHC class I antigen

MHC class I antigen

MHC class II antigen

MHC class II antigen DR alpha chain

MHC class II antigen DR52

microtubule-associated protein, RP/EB family, member 1

mitochondrial ATP synthase, H+ transporting F1 complex beta subunit

mitochondrial trifunctional protein, alpha subunit precursor

mitogen-activated protein kinase 1

mitogen-activated protein kinase kinase 1 interacting protein 1

mitogen-activated protein kinase kinase 2

moesin, isoform CRA_b

mps one binder kinase activator-like 1B

myosin IG

myosin light polypeptide 6

NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75 kDa (NADH-coenzyme Q reductase)

NCK adaptor protein 1

NECAP endocytosis associated 2

NESH protein

N-ethylmaleimide-sensitive factor attachment protein, alpha

neuroblastoma RAS viral (v-ras) oncogene homolog

neuropolypeptide h3

neutrophil adherence receptor alpha-M subunit

niban protein isoform 2

NME1-NME2 protein

nuclear chloride channel

nucleobindin 1 variant

nucleoside phosphorylase

nucleosome assembly protein 1-like 1, isoform CRA_d

Obg-like ATPase 1

otubain 1

PA2G4 protein

PDCD6IP protein

perforin-1

peroxiredoxin 1

peroxiredoxin 2

peroxiredoxin 3

peroxiredoxin 4

peroxiredoxin 6

PGAM1

PHB

phosphatase 2a

phosphatidylinositol-5-phosphate 4-kinase, type II, alpha

phosphofructokinase, liver

phosphofructokinase, platelet

phosphoglucose isomerase

phosphoglycerate kinase 1

phospholipase C, delta 1 variant

phosphoribosyl pyrophosphate synthetase 1 variant

phosphoribosylaminoimidazole carboxylase, - succinocarboxamide synthetase, isoform CRA_b

phosphoribosylformylglycinamidine synthase

phosphoserine aminotransferase 1

phostensin

poly(A) binding protein, cytoplasmic 1, isoform CRA_c

poly(rC) binding protein 1

potassium voltage-gated channel, shaker-related subfamily, beta member 2 isoform 2

PPP5C protein

profilin-1

programmed cell death protein 10

proline synthetase co-transcribed homolog

prolyl 4-hydroxylase, alpha subunit

prolyl 4-hydroxylase, beta subunit precursor

prolyl endopeptidase

proteasome (prosome, macropain) subunit, alpha type, 7(PSMA7)

proteasome 26S non-ATPase subunit 13 isoform 1

proteasome 26S subunit, ATPase, 2

proteasome 26S subunit, ATPase, 5

proteasome activator complex subunit 1 isoform 1

proteasome activator complex subunit 2

proteasome alpha 2 subunit variant

proteasome subunit, alpha type, 1

proteasome subunit, alpha type, 5

proteasome subunit, alpha type, 6

proteasome subunit, beta type, 1

proteasome subunit, beta type, 2

proteasome subunit, beta type, 4

proteasome subunit, beta type, 8

protein ARMET

protein diaphanous homolog 1

protein disulfide isomerase-associated 4

protein disulfide isomerase-related protein 5

protein disulfide-isomerase A3

protein phosphatase 1, catalytic subunit, alpha isoform 1

protein phosphatase 1, catalytic subunit, beta isoform

protein tyrosine phosphatase 1b

protein tyrosine phosphatase, non-receptor type 6 isoform 1 variant

protein-tyrosine kinase fyn isoform c

PYD and CARD domain containing

pyrophosphatase 1

pyruvate kinase 3 isoform 2

R33729_1 (Interleukin-25)

Rab GDP dissociation inhibitor beta

raftlin cell migration-inducing gene 2

Rap1a

Rap1-GTP-interacting adapter molecule

Ras GTPase-activating-like protein IQGAP2

related RAS viral (r-ras) oncogene homolog 2 isoform a

Rho GDP dissociation inhibitor (GDI) alpha

Rho GDP dissociation inhibitor (GDI) beta

Rho GTPase activating protein 1

Rho GTPase-activating protein 9

ribosomal protein L11

ribosomal protein L12

S-adenosylhomocysteine hydrolase

Sec23 homolog A

Sec23B protein

septin 2

septin 7

septin-9 delta

septin-9 gamma

serine/threonine phosphatase 1 gamma

serine/threonine-protein kinase PAK 2

serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

serine/threonine-protein phosphatase 2A regulatory subunit B

serpin peptidase inhibitor,clade B,member 1

seryl-tRNA synthetase

SH2 domain protein 1A

SH3-containing protein, Endophilin-B1

SHUJUN-1

signal transducer and activator of transcription 1, 91kDa, isoform CRA_d

similar to metallo-beta-lactamase superfamily protein

small GTP binding protein Rac2, isoform CRA_c

soc-2 suppressor of clear homolog

solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1

sorting nexin 17

sorting nexin 6

src kinase associated phosphoprotein 1 isoform 1

stathmin 1/oncoprotein 18

stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein)

stromal cell-derived factor 2-like 1 precursor

superoxide dismutase 1, soluble

syntaxin binding protein 1

syntaxin binding protein 2

syntaxin binding protein 3 variant

talin-1

tapasin isoform 3 precursor

TC4 protein

T-complex polypeptide 1

T-complex protein 1 subunit gamma

testin isoform 1

thioredoxin domain-containing protein 4 precursor

transfer RNA-Trp synthetase

transgelin-2

transketolase

translocon-associated protein subunit delta

triosephosphate isomerase 1

tripeptidyl-peptidase 1

tropomodulin 3

tropomyosin 3 isoform 2

tropomyosin 4

Tu translation elongation factor, mitochondrial

tubulin alpha 6 variant

tubulin tyrosine ligase-like family, member 12

tubulin, beta

tubulin, beta polypeptide

tumor rejection antigen (gp96) 1

tumor susceptibility gene 101

twinfilin-like protein

tyrosine kinase LCK

tyrosine-protein phosphatase non-receptor type 6

tyrosyl-tRNA synthetase

ubiquitin associated and SH3 domain containing protein A

ubiquitin specific peptidase 5 isoform 2

ubiquitin specific protease 14 isoform a

ubiquitin-conjugating enzyme E2 L3

ubiquitin-conjugating enzyme E2 N

ubiquitin-like modifier-activating enzyme 1

UDP-glucose ceramide glucosyltransferase-like 1 isoform 1

UDP-glucose pyrophosphorylase 2 isoform b

UNC-112 related protein 2 long form

unnamed protein product

UPF0550 protein C7orf28

vacuolar H+-ATPase 56,000 subunit

vacuolar protein sorting 45A

vacuolar sorting protein 33A

valosin-containing protein

vasodilator-stimulated phosphoprotein

vinculin

voltage-dependent anion channel 1

voltage-dependent anion channel 2

voltage-dependent anion channel 3

V-type proton ATPase subunit d 1

WD repeat domain 1

Wiskott-Aldrich syndrome protein

XRP2 protein

zeta-chain associated protein kinase 70kDa