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Table 1 Proteins identified in enriched secretory lysosomes from activated T cells.

From: Effector granules in human T lymphocytes: the luminal proteome of secretory lysosomes from human T cells

Protein name Spot # Predicted/annotated subcellular localisation Predicted function
100 kDa coactivator 122 ER,ME,PL biosynthesis
14-3-3 protein beta 714 CY,ME adapter
14-3-3 protein epsilon 685 CY,ME adapter
14-3-3 protein zeta/delta 708 CY,ME adapter
2',3'-cyclic-nucleotide 3'-phosphodiesterase 542 ME,NG hydrolase
26S protease regulatory subunit 6A 1037 CY,NU protein degradation
26S proteasome non-ATPase regulatory subunit 2 165 ME proteasome
3-phosphoglycerate dehydrogenase 408 ME biosythesis
acetyl-CoA acetyltransferase, cytosolic 594 CY biosynthesis
ACTB protein 525 ER,ME,EX,PL,SY cell motility
actin related protein 2 isoform b 564 EN,ER,ME trafficking
actin related protein 2/3 complex subunit 1B 590 ME,PL trafficking
actin related protein 2/3 complex subunit 2 674 EN,ME,PL,ER trafficking
actin related protein 2/3 complex subunit 3 799 EN,ME,PL,ER trafficking
actin related protein 2/3 complex subunit 4 798 ER,EX,ME,SY trafficking
actin related protein 2/3 complex subunit 5-like 804 ME trafficking
actin, alpha, cardiac muscle 570 ME cell motility
actin, gamma 1 propeptide 701 ME,EX,PL,SY cell motility
actinin, alpha 4 144 ME,NU,CY cell motility
acylamino acid-releasing enzyme 203 PL, CY hydrolase
acyl-CoA synthetase long-chain family member 4 isoform 2 199 MT,PE,ME metabolism
adenine phosphoribosyltransferase isoform b 784 ME,EX,PL biosynthesis
adenosine deaminase 550 CY,LY hydrolase
adenylosuccinate lyase 439 CY,PL biosynthesis
adenylosuccinate synthetase 1023 CY biosynthesis
adenylyl cyclase-associated protein variant 395 PL,ME trafficking
aflatoxin aldehyde reductase AFAR 1056 PL,GO redox protein
aging-associated gene 12 418 unknown unclassified
alanyl-tRNA synthetase 111 ME,PL biosynthesis
alcohol dehydrogenase class-3 587 PL,CY redox protein
aldo-keto reductase family 1, member A1 1078 PL,SY metabolism
aldolase A 560 EN,ME metabolism
aldose 1-epimerase (BLOCK25) 596 CY metabolism
aldose reductase 981 ME,EX,MT metabolism
alkyldihydroxyacetonephosphate synthase, peroxisomal 273 PE biosynthesis
alpha-tubulin 362 PL cell motility
annexin A1 615 ME,MT trafficking
annexin A11 415 MT,EX,ME trafficking
annexin A2 631 MT,EX,ME,secreted exocytosis
annexin A4 668 MT,EX,ME,SY signal trans.
annexin A5 660 MT,EX,ME,ER trafficking
annexin A6 263 MT,EX,ME,ER trafficking
annexin A7 isoform 2 504 EX,ME,PL exocytosis
ARP3 actin-related protein 3 homolog 465 EN,ER,ME trafficking
ARTS-1 136 ER,ME immunity
aryl hydrocarbon receptor interacting protein 955 unknown unclassified
asparaginyl-tRNA synthetase 306 ME biosynthesis
aspartate aminotransferase 575 CY biosynthesis
ATP citrate lyase 96 ME,EX,PL biosynthesis
ATP synthase, alpha subunit precursor 426 ER,LY,NG,SY,MT channel
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 413 LY,ME,NG,SY channel
axin interactor, dorsalization associated protein 632 unknown signal trans.
beta adrenergic receptor kinase 1 220 CY GTPase
bifunctional purine biosynthesis protein PURH 326 ME,PL mutifunctional
bleomycin hydrolase 463 CY,PL hydrolase
BolA-like protein 2 867 ME unclassified
calcium binding protein 39 622 EX unclassified
CALM3 protein 816 unknown unclassified
calreticulin precursor variant 287 ER,ME,NG,EX,PL,MT chaperone
carboxyl terminal LIM domain protein 612 ER,ME,PL,EN cell motility
catalase 361 PE,ER,LY,EN,ME metabolism
cathepsin B 691 LY,ME,NG hydrolase
cathepsin D preproprotein 696 LY,ME,NG,EX,MT hydrolase
cathepsin H 738 LY hydrolase
cathepsin S 749 LY immunity
Cbr1 In Complex With Hydroxy-Pp 666 ME redox protein
Cdc42ACK GTPASE 790 ME cell motility
centaurin beta1 214 unknown GTPase
chaperonin (HSP60) 338 ME,NG,EX,SY,MT chaperone
chaperonin containing TCP1, subunit 2β 424 ER,EN,ME,PL,MT,CY chaperone
chaperonin containing TCP1, subunit 7η 376 EN,ME,PL chaperone
chaperonin containing TCP1, subunti 5ε 339 EX,PL chaperone
chaperonin containing TCP1, subunti 8τ 357 EN,ME,EX chaperone
chaperonin containing TCP1, subunti 8τ 358 EN,ME,EX chaperone
chromatin modifying protein 4B 639 ME,EX trafficking
chromosome 20 open reading frame 3 (BSCv) 489 ME unclassified
chromosome 9 open reading frame 19 831 EX,GO unclassified
N2 protein 651 unknown unclassified
coactosin-like protein 841 PL,SY unclassified
cofilin 1 810 ER,ME,EX,MT cell motility
copine I 310 ME trafficking
copine III 340 ME,EX,PL trafficking
coronin 7 113 CY,GO trafficking
coronin, actin binding protein, 1A 371 LY,PL cell motility
coronin, actin binding protein, 1C 353 ME multifunctional
c-src tyrosine kinase 475 CY,PL signal trans.
cyclophilin A 826 ME,EX,MT chaperone
cyclophilin B 800 ER,ME chaperone
cystatin B 857 ME protein inhibitor
cysteine and glycine-rich protein 1 769 NU unclassified
cytoskeleton associated protein 952 CY cell motility
cytosolic malate dehydrogenase 642 ME,EX,PL,SY,MT metabolism
DCHT2 Serine/threonine-protein kinase OSR1 332 ME signal trans.
destrin isoform a 814 ME,EX,MT cell motility
differentially expressed in FDCP 6 homolog (mouse), isoform CRA_b 228 unknown unclassified
dihydropyrimidinase-like 2 319 SY signal trans.
dimethylarginine dimethylaminohydrolase 2 683 unknown hydrolase
dipeptidyl peptidase 4 81 ER,LY,EN,ME,EX hydrolase
DJ-1 protein 764 ME,PL,SY,MT redox protein
DnaJ (Hsp40) homolog, subfamily A, member 1, isoform CRA_d 499 ER,ME chaperone
DnaJ (Hsp40) homolog, subfamily B, member 11 precursor 551 ER chaperone
docking protein 2 455 unknown unclassified
dynamin 2 isoform 1 148 EN trafficking
echinoderm microtubule associated protein like 2 variant 929 CY cell motility
EF-hand domain family, member D2 1012 unknown unclassified
EH-domain containing 1 342 ER,LY,EN,EX,PL trafficking
Ena-VASP-like protein 447 CY cell motility
ENC-1AS aka Beta-hexosaminidase subunit beta 431 LY multifunctional
endoplasmic reticulum protein 29 isoform 1 precursor 721 ER,ME,PL chaperone
enolase 1 variant 496 ME,EX,SY,MT metabolism
ERAP2 protein 99 ER immunity
ERBB2IP protein 197 NU,CY multifunctional
ERO1L 311 ME,ER redox protein
esterase D/formylglutathione hydrolase 656 ME hydrolase
eukaryotic translation elongation factor 1 alpha 1 462 ER,LY,EN,ME,EX,PL biosynthesis
eukaryotic translation elongation factor 1 gamma, isoform CRA_d 947 ME biosynthesis
eukaryotic translation elongation factor 2 158 ER,EN,ME,EX biosynthesis
eukaryotic translation initiation factor 4A 505 ME biosynthesis
eukaryotic translation initiation factor 5A 817 ME biosynthesis
extended-synaptotagmin-1 KIAA0747 protein 155 ME unclassified
ezrin 208 CY cell motility
F-actin capping protein alpha-1 subunit 611 ER,EN,ME actin binding
F-actin capping protein alpha-1 subunit variant 623 ER,EN,ME actin binding
F-actin capping protein alpha-2 subunit 616 ER,EN,ME,PL cell motility
F-actin capping protein beta subunit 663 ER,EN,ME actin binding
farnesyl pyrophosphate synthetase 579 CY biosynthesis
FK506 binding protein 1A 856 ME,SY,MT signal trans.
flotillin 1 486 LY,ME,EX membrane
formin-binding protein 1 1059 SL, LY, CY adapter
fructose-bisphosphate aldolase C 565 ME,SY,MT metabolism
fumarate hydratase, mitochondrial 507 EN,SY,MT cell cycle
FYN-binding protein 71 CY,NU adapter
G protein beta subunit 638 ME,MT signal trans.
galectin-1 851 ME,PL immunity
galectin-3 718 ME,NU immunity
gamma-enolase 476 ME,PL,SY glycolysis
gamma-glutamyl hydrolase 629 LY,ME,NG,PL hydrolase
GDP-mannose pyrophosphorylase A 541 unknown biosythesis
gelsolin-like capping protein isoform 9 572 ME,CY,NU cell motility
GIPC1 protein 598 SY,CY protein binding
glia maturation factor gamma 818 unknown unclassified
glucosamine-6-phosphate deaminase 1 677 CY hydrolase
glucose-6-phosphate dehydrogenase isoform b 409 ME metabolism
glucosidase II subunit beta 126 ER,ME,PL hydrolase
glucosidase, alpha; neutral AB, isoform CRA_a 936 ER,ME,PL hydrolase
glutamate carboxypeptidase 430 unknown hydrolase
glutamate Dehydrogenase-Apo Form 437 ER,ME,PL,MT unclassified
glutaredoxin 3 589 CY redox protein
glutathione S-transferase P1 766 ER,ME,EX,PL metabolism
glutathione synthetase 461 PL redox protein
glutathione-S-transferase kappa 1 765 PL,ME,MT,PE unclassified
glutathione-S-transferase omega 1 698 LY,ME,NG,EX,PL,SY,MT metabolism
glyceraldehyde-3-phosphate dehydrogenase 610 LY,ME,NG,EX,PL,SY,MT metabolism
glycyl-tRNA synthetase 244 ME biosynthesis
glyoxalase domain containing 4 653 MT unclassified
GNAS complex locus isoform f 531 EX multifunctional
GNB1 protein 634 EN,ME,EX,PL,SY signal trans.
granzyme A 724 SL immunity
GRAP2 protein 957 unknown unclassified
GRB2 protein 756 SY adapter
GTP-binding nuclear protein Ran 755 ME,EX trafficking
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, isoform CRA_c 582 EX GTPase
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, isoform CRA_d 664 ER signal trans.
guanine nucleotide-binding protein G(k) subunit alpha 585 ME,EX trafficking
guanine nucleotide-binding protein subunit alpha-13 989 ME signal trans.
haloacid dehalogenase-like hydrolase domain containing 2 690 unknown hydrolase
heat shock 70kDa protein 1A 278 ER,EN,ME,EX,MT chaperone
heat shock 70kDa protein 5 226 ER,ME,EX,PL,MT chaperone
heat shock 70kDa protein 8 isoform 1 259 LY,ME,NG,EX,PL,SY,MT chaperone
heat shock 70kDa protein 8 isoform 1 260 LY,ME,NG,EX,PL,SY,MT chaperone
heat shock protein 70 112 EX chaperone
heat shock protein HSP 90-alpha 969 ME,NG,MT chaperone
heat shock protein HSP 90-beta 177 ME,EX,MT chaperone
hematopoietic cell-specific Lyn substrate 1 181 CY,MT signal trans.
HEXA protein 422 LY multifunctional
hexose-6-phosphate dehydrogenase 194 ER metabolism
HIP-55 377 CY signal trans.
histidine triad nucleotide binding protein 1 852 ME,PL,SY hydrolase
histocompatibility (minor) HA-1 1072 unknown GTPase
hypothetical protein 216 unknown unclassified
hypothetical protein LOC79624 472 unknown unclassified
hypoxia up-regulated protein 1 47 ER,PL,ME chaperone
importin subunit beta-1 164 ME trafficking
integrin beta-2 80 PL membrane
interleukin-16 210 secreted immunity
isocitrate dehydrogenase 1 (NADP+), soluble, isoform CRA_b 540 ME,EX,PL redox protein
isocitrate dehydrogenase 2 (NADP+), mitochondrial, isoform CRA_b 510 PL,MT redox protein
kinase/transmembrane domain fusion protein 1061 unknown unclassified
laminin-binding protein 543 ME,ER cell adhesion
leucine aminopeptidase 3 432 CY protein degradation
leucine rich repeat containing 57 747 unknown unclassified
leucine-rich repeat and calponin homology domain-containing protein 5 908 MT protein binding
leucocyte antigen CD97 872 ME,secreted cell adhesion
leukocyte-derived arginine aminopeptidase long form variant 102 unknown hydrolase
leukotriene A4 hydrolase 309 CY hydrolase
LIM and SH3 domain protein 1 606 ER,EN,ME,PL adapter
LIM domain-containing protein 2 834 unknown unclassified
lin 7 homolog c 1070 SY exocytosis
L-lactate dehydrogenase 645 ME,EX,SY metabolism
L-lactate dehydrogenase B chain 626 ME,EX,PL,SY,MT redox protein
L-plastin 266 CY actin binding
L-plastin variant 267 unknown cell motility
LPXN protein 474 unknown unclassified
lymphocyte cytosolic protein 2 229 CY immunity
lymphocyte-specific protein 1 959 PL immunity
lysosomal acid alpha-mannosidase 265 LY,ME hydrolase
M2-type pyruvate kinase 356 ME,EX,SY metabolism
Macrophage Migration Inhibitory Factor (Mif) With Hydroxphenylpyruvate 862 ME,EX,PL,SY immunity
MAGUK p55 subfamily member 7 292 PL protein binding
methylenetetrahydrofolate dehydrogenase 1 139 EN,ME,PL,MT multifunctional
methylthioadenosine phosphorylase 697 CY metabolism
MHC class I antigen 533 ME immunity
MHC class I antigen 865 ME immunity
MHC class II antigen 953 ME immunity
MHC class II antigen DR alpha chain 1050 LY immunity
MHC class II antigen DR52 1083 ME immunity
microtubule-associated protein, RP/EB family, member 1 665 ME,PL cell motility
mitochondrial ATP synthase, H+ transporting F1 complex beta subunit 443 MT trafficking
mitochondrial trifunctional protein, alpha subunit precursor 253 PL, MT metabolism
mitogen-activated protein kinase 1 569 ME,PL signal trans.
mitogen-activated protein kinase kinase 1 interacting protein 1 943 LY adapter
mitogen-activated protein kinase kinase 2 509 unknown signal trans.
moesin, isoform CRA_b 246 EN,ME,EX,PL,MT cell motility
mps one binder kinase activator-like 1B 758 unknown unclassified
myosin IG 75 unknown trafficking
myosin light polypeptide 6 830 ME cell motility
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75 kDa (NADH-coenzyme Q reductase) 896 ER,ME,MT trafficking
NCK adaptor protein 1 506 CY,ER adapter
NECAP endocytosis associated 2 1010 EN trafficking
NESH protein 434 unknown unclassified
N-ethylmaleimide-sensitive factor attachment protein, alpha 652 ME,NG,PL trafficking
neuroblastoma RAS viral (v-ras) oncogene homolog 779 GO,CY trafficking
neuropolypeptide h3 781 ME,EX,SY protein inhibitor
neutrophil adherence receptor alpha-M subunit 36 membrane cell adhesion
niban protein isoform 2 38 CY signal trans.
NME1-NME2 protein 823 CY,NU multifunctional
nuclear chloride channel 684 ME,EX,PL,MT channel
nucleobindin 1 variant 335 unknown unclassified
nucleoside phosphorylase 670 CY,PL cell cycle
nucleosome assembly protein 1-like 1, isoform CRA_d 315 ME,PL,NU cell cycle
Obg-like ATPase 1 511 EN,ME,PL hydrolase
otubain 1 637 ME hydrolase
PA2G4 protein 490 unknown unclassified
PDCD6IP protein 171 unknown unclassified
perforin-1 280 SL immunity
peroxiredoxin 1 774 ER,LY,EN,ME,NG,PL,MT redox protein
peroxiredoxin 2 778 ER,EN,ME,SY,MT redox protein
peroxiredoxin 3 768 ME,PL,MT redox protein
peroxiredoxin 4 737 ER,EN,ME redox protein
peroxiredoxin 6 945 LY,ME,EX,PL,SY redox protein
PGAM1 730 ME,EX,SY metabolism
PHB 948 unknown unclassified
phosphatase 2a 316 MT multifunctional
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 457 NG,PL metabolism
phosphofructokinase, liver 939 unknown glycolysis
phosphofructokinase, platelet 196 ME,PL glycolysis
phosphoglucose isomerase 390 ME,EX,PL,MT multifunctional
phosphoglycerate kinase 1 537 ME,EX,SY,MT metabolism
phospholipase C, delta 1 variant 178 unknown signal trans.
phosphoribosyl pyrophosphate synthetase 1 variant 1080 unknown biosynthesis
phosphoribosylaminoimidazole carboxylase, - succinocarboxamide synthetase, isoform CRA_b 523 EN,SY multifunctional
phosphoribosylformylglycinamidine synthase 64 CY biosynthesis
phosphoserine aminotransferase 1 988 ME biosynthesis
phostensin 91 CY unclassified
poly(A) binding protein, cytoplasmic 1, isoform CRA_c 256 ER,EN,ME,PL metabolism
poly(rC) binding protein 1 1082 ME,CY,NU unclassified
potassium voltage-gated channel, shaker-related subfamily, beta member 2 isoform 2 635 CY channel
PPP5C protein 364 CY,NU hydrolase
profilin-1 848 ME,EX,PL,MT actin binding
programmed cell death protein 10 741 unknown apoptosis
proline synthetase co-transcribed homolog 699 CY unclassified
prolyl 4-hydroxylase, alpha subunit 337 ER,ME redox protein
prolyl 4-hydroxylase, beta subunit precursor 348 ER,ME,EX,PL,MT redox protein
prolyl endopeptidase 234 CY protein degradation
proteasome (prosome, macropain) subunit, alpha type, 7(PSMA7) 729 CY,Proteasom hydrolase
proteasome 26S non-ATPase subunit 13 isoform 1 577 ME proteasome
proteasome 26S subunit, ATPase, 2 498 CY,NU unclassified
proteasome 26S subunit, ATPase, 5 514 CY,NU unclassified
proteasome activator complex subunit 1 isoform 1 703 PL,MT immunity
proteasome activator complex subunit 2 689 ME immunity
proteasome alpha 2 subunit variant 754 CY hydrolase
proteasome subunit, alpha type, 1 687 ME hydrolase
proteasome subunit, alpha type, 5 1009 ME hydrolase
proteasome subunit, alpha type, 6 734 CY,NU hydrolase
proteasome subunit, beta type, 1 750 ME,CY hydrolase
proteasome subunit, beta type, 2 780 CY,NU hydrolase
proteasome subunit, beta type, 4 944 CY,NU hydrolase
proteasome subunit, beta type, 8 773 PL,CY,NU immunity
protein ARMET 805 ME, secreted unclassified
protein diaphanous homolog 1 45 ME cell motility
protein disulfide isomerase-associated 4 1060 ER,ME,PL chaperone
protein disulfide isomerase-related protein 5 458 ER,ME chaperone
protein disulfide-isomerase A3 379 ER,LY,ME,NG,EX,PL chaperone
protein phosphatase 1, catalytic subunit, alpha isoform 1 603 EX hydrolase
protein phosphatase 1, catalytic subunit, beta isoform 617 ME,PL hydrolase
protein tyrosine phosphatase 1b 536 ME,ER hydrolase
protein tyrosine phosphatase, non-receptor type 6 isoform 1 variant 317 unknown hydrolase
protein-tyrosine kinase fyn isoform c 373 EN,CY signal trans.
PYD and CARD domain containing 771 CY apoptosis
pyrophosphatase 1 654 ME,MT hydrolase
pyruvate kinase 3 isoform 2 346 ME,EX,SY metabolism
R33729_1 (Interleukin-25) 837 ME,secreted signal trans.
Rab GDP dissociation inhibitor beta 469 ME,EX,PL,MT GTPase
raftlin cell migration-inducing gene 2 193 PL unclassified
Rap1a 785 EN,ME,MT GTPase
Rap1-GTP-interacting adapter molecule 141 CY signal trans.
Ras GTPase-activating-like protein IQGAP2 1069a EN signal trans.
related RAS viral (r-ras) oncogene homolog 2 isoform a 1049 LY,ME,EX GTPase
Rho GDP dissociation inhibitor (GDI) alpha 716 ME,PL,MT GTPase
Rho GDP dissociation inhibitor (GDI) beta 728 CY GTPase
Rho GTPase activating protein 1 441 PL GTPase
Rho GTPase-activating protein 9 998 unknown GTPase
ribosomal protein L11 797 ribosome biosynthesis
ribosomal protein L12 809 EN,ribosom biosynthesis
S-adenosylhomocysteine hydrolase 513 ME hydrolase
Sec23 homolog A 221 ER,ME,PL trafficking
Sec23B protein 1001 EN trafficking
septin 2 554 ME,EX,SY unclassified
septin 7 484 ME,PL,SY unclassified
septin-9 delta 558 ME unclassified
septin-9 gamma 973 ME unclassified
serine/threonine phosphatase 1 gamma 985 MT,SY hydrolase
serine/threonine-protein kinase PAK 2 352 PL signal trans.
serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 621 MT signal trans.
serine/threonine-protein phosphatase 2A regulatory subunit B 592 NU signal trans.
serpin peptidase inhibitor,clade B,member 1 548 CY protein inhibitor
seryl-tRNA synthetase 365 ME,PL tRNA processing
SH2 domain protein 1A 840 CY signal trans.
SH3-containing protein, Endophilin-B1 1081 CY,GO,MT apoptosis
SHUJUN-1 795 CY cell motility
signal transducer and activator of transcription 1, 91kDa, isoform CRA_d 188 CY,NU signal trans.
similar to metallo-beta-lactamase superfamily protein 686 unknown hydrolase
small GTP binding protein Rac2, isoform CRA_c 1006 unknown signal trans.
soc-2 suppressor of clear homolog 318 CY unclassified
solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1 460 ME,EX,PL scaffolding
sorting nexin 17 421 EN,ME,PL trafficking
sorting nexin 6 466 CY trafficking
src kinase associated phosphoprotein 1 isoform 1 417 CY,NU signal trans.
stathmin 1/oncoprotein 18 820 SY cell motility
stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) 323a ME,PL,SY chaperone
stromal cell-derived factor 2-like 1 precursor 767 ER unclassified
superoxide dismutase 1, soluble 806 ME,EX,MT redox protein
syntaxin binding protein 1 305 ME,NG,EX,PL,SY trafficking
syntaxin binding protein 2 302 EX,PL trafficking
syntaxin binding protein 3 variant 294 ME,PL trafficking
talin-1 920 EN,ME,PL cell motility
tapasin isoform 3 precursor 495 ER,ME immunity
TC4 protein 736 NU GTPase
T-complex polypeptide 1 1030 ER,EN,ME,EX chaperone
T-complex protein 1 subunit gamma 307 CY chaperone
testin isoform 1 456 unknown unclassified
thioredoxin domain-containing protein 4 precursor 502 ER,ME,PL scaffolding
transfer RNA-Trp synthetase 411 ME,PL biosynthesis
transgelin-2 787 ME,MT unclassified
transketolase 276 ME,EN unclassified
translocon-associated protein subunit delta 811 ME,ER trafficking
triosephosphate isomerase 1 742 ME,EX,SY,MT unclassified
tripeptidyl-peptidase 1 992 LY,ME,NG,PL,MT protein degradation
tropomodulin 3 561 ER,ME cell motility
tropomyosin 3 isoform 2 676 unknown unclassified
tropomyosin 4 672 ME unclassified
Tu translation elongation factor, mitochondrial 517 LY,ME,PL,MT biosynthesis
tubulin alpha 6 variant 363 ME,PL cell motility
tubulin tyrosine ligase-like family, member 12 897 ME trafficking
tubulin, beta 407 ME,PL,SY cell motility
tubulin, beta polypeptide 433 ME,PL,SY cell motility
tumor rejection antigen (gp96) 1 118 ER,ME,PL,GO chaperone
tumor susceptibility gene 101 470 EX trafficking
twinfilin-like protein 578 CY cell motility
tyrosine kinase LCK 399 CY signal trans.
tyrosine-protein phosphatase non-receptor type 6 325 CY,NU signal trans.
tyrosyl-tRNA synthetase 366 ME,PL signal trans.
ubiquitin associated and SH3 domain containing protein A 913 CY,NU protein degradation
ubiquitin specific peptidase 5 isoform 2 154 LY,ME,NG protein degradation
ubiquitin specific protease 14 isoform a 344 PL protein degradation
ubiquitin-conjugating enzyme E2 L3 882 MT protein degradation
ubiquitin-conjugating enzyme E2 N 839 ME,EX,MT differentiation
ubiquitin-like modifier-activating enzyme 1 120 MT,ME protein degradation
UDP-glucose ceramide glucosyltransferase-like 1 isoform 1 39 ER,ME chaperone
UDP-glucose pyrophosphorylase 2 isoform b 442 EN,ME metabolism
UNC-112 related protein 2 long form 971 PL cell adhesion
unnamed protein product 706 unknown unclassified
UPF0550 protein C7orf28 450 ME unclassified
vacuolar H+-ATPase 56,000 subunit 414 LY,ME,NG,SY channel
vacuolar protein sorting 45A 322 LY,EN trafficking
vacuolar sorting protein 33A 1067 EN,LY trafficking
valosin-containing protein 159 unknown unclassified
vasodilator-stimulated phosphoprotein 503 PL cell motility
vinculin 108 ME cell motility
voltage-dependent anion channel 1 658 ER,LY,ME,NG,EX,PL,SY,MT channel
voltage-dependent anion channel 2 657 SY,MT channel
voltage-dependent anion channel 3 688 EN,ME,MT channel
V-type proton ATPase subunit d 1 599 LY,EN,ME,SY channel
WD repeat domain 1 304 EN,ME,EX cell motility
Wiskott-Aldrich syndrome protein 323b CY cell motility
XRP2 protein 546 ME signal trans.
zeta-chain associated protein kinase 70kDa 277 CY signal trans.
  1. 397 individual proteins were identified to be associated with enriched secretory lysosomes from human T cell blasts. The proteins are listed by name, followed by individual spot numbers and the predicted/annotated subcellular localisation and function. Abbreviations: LY: lysosomes, ME: melanosomes, PL: platelet granules, SY: synaptosomes, EX: exosomes, CG: cytotoxic granules, NG: neuromelanin granules, EN: endosomes, MT: mitochondria, GO: Golgi, PE: peroxisomes, CY: cytoplasm, ER: endoplasmic reticulum and NU: nucleus. For detailed information on individual spots/proteins, please refer to the additional files.