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Figure 6 | Cell Communication and Signaling

Figure 6

From: The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2

Figure 6

Importance of CadF for C. jejuni- induced FAK, EGFR and PDGFR activation. (A) FAK-positive fibroblasts were infected with wt C. jejuni F38011 or isogenic F38011ΔcadF for indicated periods of time. FAK, EGFR or PDGFR activation was analysed by immunoblotting with indicated antibodies. Total PDGFR expression levels were determined as loading control. (B) Quantification of FAK, EGFR and PDGFR kinase phosphorylation during the course of infection. One hundred % of activity corresponds to the highest amount of phosphorylation detected per experiment and selected kinase (lane 5). (C) Intracellular C. jejuni were quantified by gentamicin protection assays. (*) P ≤ 0.005 and (**) P ≤ 0.005 were considered as statistically significant.

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