Figure 3
From: The secret life of kinases: functions beyond catalysis
Kinase-independent functions of Raf kinases. (A) General structure of MAPK pathways. (B) Raf-1 controls cell migration and differentiation by inhibiting the Rho effector kinase ROK-α. (C) Raf-1 controls TNF- and Fas-mediated apoptosis by inhibiting apoptosis signal-regulating kinase-1 (ASK). (D) Raf-1 and A-Raf bind and inhibit the pro-apoptotic mammalian sterile 20-like kinase (MST2) thereby interfering with its dimerization, autophosphorylation, and activation.