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Table 1 MAMs proteins involved in ER-mitochondria Ca2+ cross-talk and relative functions

From: Calcium signaling around Mitochondria Associated Membranes (MAMs)

ACRONYM

FULL NAME

FUNCTION

LITERATURE

AKT/PKB

protein kinase B

Ca2+ signaling, apoptosis

[70]

PP2a

Protein phosphatase 2

Ca2+ signaling, apoptosis

[70]

ANT

adenine nucleotide translocase

Part of mitochondrial contact sites and/or PTP

[71]

BAP31

B-cell receptor-associated protein 31

Ca2+ signaling, apoptosis

[72]

Carleticulin

carleticulin

Ca2+ handling

[73]

ERp44

endoplasmic reticulum resident protein 44

Ca2+ handling

[74]

grp75

glucose-regulated protein 75

Ca2+ handling

[62]

grp78

78 kDa glucose-regulated protein

Ca2+ handling

[75]

IP3R

inositol 1,4,5-triphosphate receptor

Ca2+ handling

[62, 76]

p66Shc

the 66 kDa isoform of ShcA protein

ROS production and signal transduction

[69]

PACS-2

phosphofurin acidic cluster sorting protein 2

Protein sorting, Ca2+ handling

[77]

PEMT2

phosphatidylethanolamine N-methyltransferase 2

Lipids synthesis

and trafficking

[78]

PML

promyelocytic leukemia protein

Ca2+ handling

[70]

PSS-1 and -2

phosphatidylserine synthase 1 and 2

Lipids synthesis

and trafficking

[79]

Serca2b

sarcoplasmic reticulum calcium ATPase 2b

Ca2+ handling

[80]

Sig-1R

sigma-1 receptor

Ca2+ handling

[63]

tSERCA1

truncated sarco(endo)plasmic reticulum Ca2+ ATPase

Ca2+ leak from ER

[81]

VDAC

voltage-dependent anion channel

Chanel, Ca2+ handling

[76]

sphingolipid-specific Glc-T

sphingolipid-specific glycosyltransferases

Lipids synthesis

and trafficking

[82]

S100B

S100 calcium binding protein B

Lipids synthesis

and trafficking,

MAM stabilization

[83, 84]

apoE, apoB and apoC

apolipoproteins

lipid trafficking

[79, 85]

p58

58 kDa protein

lipid trafficking

[79]

DGAT

diacylglycerol acyltransferase

Lipids synthesis

[79]

Ankyrin-B

ankyrin-B

Ca2+ handling

[86]

CNX

calnexin

Ca2+ handling

[80, 87]

Bcl-2

B-cell lymphoma 2 protein

Ca2+ homeostasis, apoptosis

[88]

Bcl-XL

B-cell lymphoma-extra large protein

Ca2+ homeostasis, apoptosis

[88]

MFN 1 and 2

Mitofuzin 1 and 2

MAM stabilization

[23]

TIM & TOM complexes

Transporter Inner Membrane complex & Transporter Outer Membrane complex

Protein transport

[89, 90]

vMIA/HCMV

The human cytomegalovirus

ERmitochondrial

cross-talk

[91]

p7 and NS5B protein

proteins of hepatitis C virus

ERmitochondrial

cross-talk

[92]

ACAT

acyl- CoA:cholesterol acyltransferase

Lipids synthesis

[79]

Ero1α

ER oxidase 1 alpha

Ca2+ signaling

[93]