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Table 1 MAMs proteins involved in ER-mitochondria Ca2+ cross-talk and relative functions

From: Calcium signaling around Mitochondria Associated Membranes (MAMs)

ACRONYM FULL NAME FUNCTION LITERATURE
AKT/PKB protein kinase B Ca2+ signaling, apoptosis [70]
PP2a Protein phosphatase 2 Ca2+ signaling, apoptosis [70]
ANT adenine nucleotide translocase Part of mitochondrial contact sites and/or PTP [71]
BAP31 B-cell receptor-associated protein 31 Ca2+ signaling, apoptosis [72]
Carleticulin carleticulin Ca2+ handling [73]
ERp44 endoplasmic reticulum resident protein 44 Ca2+ handling [74]
grp75 glucose-regulated protein 75 Ca2+ handling [62]
grp78 78 kDa glucose-regulated protein Ca2+ handling [75]
IP3R inositol 1,4,5-triphosphate receptor Ca2+ handling [62, 76]
p66Shc the 66 kDa isoform of ShcA protein ROS production and signal transduction [69]
PACS-2 phosphofurin acidic cluster sorting protein 2 Protein sorting, Ca2+ handling [77]
PEMT2 phosphatidylethanolamine N-methyltransferase 2 Lipids synthesis and trafficking [78]
PML promyelocytic leukemia protein Ca2+ handling [70]
PSS-1 and -2 phosphatidylserine synthase 1 and 2 Lipids synthesis and trafficking [79]
Serca2b sarcoplasmic reticulum calcium ATPase 2b Ca2+ handling [80]
Sig-1R sigma-1 receptor Ca2+ handling [63]
tSERCA1 truncated sarco(endo)plasmic reticulum Ca2+ ATPase Ca2+ leak from ER [81]
VDAC voltage-dependent anion channel Chanel, Ca2+ handling [76]
sphingolipid-specific Glc-T sphingolipid-specific glycosyltransferases Lipids synthesis and trafficking [82]
S100B S100 calcium binding protein B Lipids synthesis and trafficking, MAM stabilization [83, 84]
apoE, apoB and apoC apolipoproteins lipid trafficking [79, 85]
p58 58 kDa protein lipid trafficking [79]
DGAT diacylglycerol acyltransferase Lipids synthesis [79]
Ankyrin-B ankyrin-B Ca2+ handling [86]
CNX calnexin Ca2+ handling [80, 87]
Bcl-2 B-cell lymphoma 2 protein Ca2+ homeostasis, apoptosis [88]
Bcl-XL B-cell lymphoma-extra large protein Ca2+ homeostasis, apoptosis [88]
MFN 1 and 2 Mitofuzin 1 and 2 MAM stabilization [23]
TIM & TOM complexes Transporter Inner Membrane complex & Transporter Outer Membrane complex Protein transport [89, 90]
vMIA/HCMV The human cytomegalovirus ERmitochondrial cross-talk [91]
p7 and NS5B protein proteins of hepatitis C virus ERmitochondrial cross-talk [92]
ACAT acyl- CoA:cholesterol acyltransferase Lipids synthesis [79]
Ero1α ER oxidase 1 alpha Ca2+ signaling [93]