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Figure 2 | Cell Communication and Signaling

Figure 2

From: Calcium signaling around Mitochondria Associated Membranes (MAMs)

Figure 2

PML and p66Shc regulates cell span at the MAMs level. The tumor suppressor PML in resting conditions resides in a specific multi-protein complex with IP3R, PP2a and AKT, essential for a normal Ca2+ flux from ER to mitochondria and, consequently, for correct apoptosis levels (upper panel). Aging and ROS determine phosphorylation and accumulation of p66Shc in the MAMs fraction. The presence of phospho-p66Shc at the mitochondrial level determines alterations in mitochondrial homeostasis, including Ca2+ signalling, and ultimately increases apoptotic and senescence responses (lower panel).

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