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Table 1 Phosphorylation of the PDZ ligand by serine or threonine kinase modulates PDZ protein-protein interactions

From: PDZ domains and their binding partners: structure, specificity, and modification

PDZ-containing proteins

Binding partner(s)

PDZ liganda

Kinase(s)

Ref.

PSD-95

Kir2.3

ISYRREES RI

PKA (RR/KXS/T)b

Cohen et al. [187]

PSD-95

Stargazin

ANRRTT PV

PKA (RR/KXS/T)b

Choi et al. [115]

Chetkovich et al. [114]

PSD-95/SAP102

NR2B subunit of NMDAR

LSSIES DV

CK2 (S/T XXE/D)b

Chung et al. [112]

GRIP1

GluR2 subunit of AMPAR

YNYGIES VKI

PKC (RXXS/T XR/K)b

Matsuda et al. [116]

Chung et al. [117]

PSD-95

NR2C subunit of NMDAR

RRVSS LESEV

PKA/PKC

Chen et al. [127]

PSD-95/SAP97

LRP4

ERKLS SESQV

CaMKII (RXXS/T) b

Tian et al. [119]

  1. a Phosphorylation sites of PDZ ligands are underlined and in bold.
  2. b Kinase consensus phosphorylation motif (where X indicates any amino acid) [188, 189].