Figure 5

Interaction map for some of the dystroglycan cytoplasmic domain interacting proteins discussed in this review. A. Individual named proteins are represented as circles (caveolin-3; Cav-3, dystroglycan; DG) with binding interactions between each them represented by green lines. Competing and regulatory interactions or mutually exclusive interactions are represented by red lines, e.g. phosphorylation of DG by Src prevents utrophin or dystrophin binding so a red line is drawn between Src and utrophin or dystrophin, Caveolin-3 and dystrophin both bind to and compete for the same site on DG, so a red line is drawn between them. B-D represents clusters of interactions that are more specific to the different types of adhesion structure mentioned in the text. Focal adhesion interactions are outlined in blue (B), podosome interactions are outlined in yellow (C) and costameric interactions in magenta (D). E shows an overlay of all of these interaction groups and highlights the central role of the DG-Src axis in acting as a molecular switch to control the various functions and interactions of dystroglycan.