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Table 2 Proteins exhibiting increased phosphorylation in N2a58/22L cells.

From: Quantitative phosphoproteomic analysis of prion-infected neuronal cells

No.

Uniprot

Protein Names

Ratioa

Pept.b

Sequence

Coverage

[%]

PEPc

Biological

Process

76

P80316

T-complex protein 1 subunit epsilon

1.017

1

6.1

8.63E-18

protein folding

77

Q9CX22

Putative uncharacterized protein; Cofilin-1

1.0173

5

29.7

3.72E-41

cytoskeleton; protein phosphorylation

78

P32067

Lupus La protein homolog

1.02

2

7.5

1.68E-02

RNA processing

79

A6ZI44

Fructose-bisphosphate aldolase

1.0328

8

12.2

2.75E-25

glycolysis

80

P35700

Peroxiredoxin-1

1.0342

6

6.7

2.44E-10

proliferation; redox homeostasis; stress response

81

P05202

Aspartate aminotransferase, mitochondrial

1.0344

1

12.3

1.04E-11

aspartate biosynthesis; oxaloacetate metabolism

82

Q3TFD0

Serine hydroxymethyltransferase

1.0425

3

6.5

2.95E-03

carbon metabolism

83

P63101

14-3-3 protein zeta/delta

1.0478

19

19.2

7.09E-27

protein binding

84

Q9CZ30-1

Obg-like ATPase 1

1.0606

3

7.1

2.25E-16

ATP/GTP binding; hydrolase activity

85

P06745

Glucose-6-phosphate isomerase

1.0652

3

7.7

3.34E-15

angiogenesis; gluconeogenesis; glycolysis

86

Q71H74

Collapsin response mediator protein 4A

1.0688

5

6.3

6.94E-12

nervous system development

87

Q6P5F9

Exportin-1

1.0703

2

3.6

2.74E-20

nuclear export; centrosome duplication

88

Q01853

Transitional endoplasmic reticulum ATPase

1.0708

2

3.7

2.97E-05

apoptosis; retrograde protein transport

89

Q3TCI7

L-lactate dehydrogenase

1.0746

4

18.3

1.43E-32

glycolysis

90

P08113

Endoplasmin

1.08

1

2.6

1.05E-05

protein folding

91

Q8VC46

Ubc protein;Ubiquitin

1.0848

17

30.7

2.18E-06

protein binding

92

A0PJ96

Mtap1b protein

1.0871

2

3.2

2.72E-13

cytoskeleton

93

Q61171

Peroxiredoxin-2

1.0934

2

9.1

4.16E-04

signal transduction; redox homeostasis

94

Q9WVA4

Transgelin-2

1.106

2

11.8

9.37E-05

muscle organ development

95

P52480-1

Pyruvate kinase isozymes M1/M2

1.1081

3

22.2

6.30E-39

glycolysis

96

O08709

Peroxiredoxin-6

1.1204

5

13.8

1.10E-04

redox homeostasis

97

P17182

Alpha-enolase

1.128

11

41.5

6.35E-26

glycolysis

98

P54227

Stathmin

1.1422

4

18.1

1.94E-02

cell cycle; cytoskeleton

99

Q922F4

Tubulin beta-6 chain

1.1427

1

19.2

1.01E-25

cytoskeleton

100

Q60864

Stress-induced-phosphoprotein 1

1.1499

1

3.5

5.12E-05

stress response

101

P52480-2

Pyruvate kinase isozymes M1/M2

1.2958

1

19.6

3.40E-33

glycolysis

102

Q920E5

Farnesyl pyrophosphate synthetase

1.3534

1

8.2

8.44E-16

cholesterol/isoprenoid biosynthesis

103

P38647

Stress-70 protein, mitochondrial

1.357

2

4.6

6.57E-08

nuclear export; protein folding

104

P14824

Annexin A6

1.6252

4

7.9

2.47E-08

Ca2+ transport; muscle contraction

105

Q61753

D-3-phosphoglycerate dehydrogenase

1.7927

3

8.1

6.28E-15

cell cycle; neural development; serine biosynthesis

  1. a. Ratio of N2a58/22L vs. N2a58# cells
  2. b. Number of identified peptides
  3. c. posterior error probability (PEP) estimates the probability of wrong assignment of a spectrum to a peptide sequence