Figure 2
From: The role of the tissue microenvironment in the regulation of cancer cell motility and invasion
Scanning electron microscopy image of mesenchymally invading cells. K4 sarcoma cells were seeded on the acellular dermis [74] in the absence (left) or presence (right) of a broad-spectrum MMP-inhibitor (GM6001). In the absence of the inhibitor, K4 cells extensively degrade the matrix, whereas in the presence of the inhibitor they are not able to invade, and the matrix remains mostly intact.