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Figure 2 | Cell Communication and Signaling

Figure 2

From: P66shc and its downstream Eps8 and Rac1 proteins are upregulated in esophageal cancers

Figure 2

Expression of eps8, rac1, grb2 and ras proteins in esophageal cancers. Representative immunoblot showing the elevated levels of expression of A Eps8 from poorly differentiated (PD), Moderately differentiated (MD) and well differentiated (WD) esophageal squamous cell carcinoma and esophageal adenocarcinoma samples (lower panel). Vinculin polyclonal antibody was used as loading control. B Immunoblot analysis of Rac1, in the PD, MD, WD esophageal squamous and adenocarcinoma. C Immunoblot showing the expression of Grb2 and Ras proteins in PD, MD, WD esophageal squamous and adenocarcinoma. D Bar chart comparing the expression level of Eps8, Rac1, Grb2 and Ras proteins in esophageal cancers with respect to adjacent normals (N). Values are expressed as fold increase compared to adjacent normal. Columns, mean of fold increase in expression of four separate experiments, bars ± SE. * indicates stastically significant (p < 0.05) differences compared with adjacent normals as control using t test.

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