Skip to main content
Figure 1 | Cell Communication and Signaling

Figure 1

From: P66shc and its downstream Eps8 and Rac1 proteins are upregulated in esophageal cancers

Figure 1

Expression of p66shc protein in esophageal cancers. A Representative immunoblot showing the up-regulation of p66shc protein in poorly differentiated (PD), Moderately differentiated (MD) and well differentiated (WD) esophageal squamous cell carcinoma with respect to adjacent normals (N). Vinculin polyclonal antibody was used as loading control (Lower Panel). B Upregulation of p66shc was also confirmed with antibody which reacts with all the three Shc isoforms. C Immunoblot showing the up-regulation of p66shc protein in esophageal adenocarcinoma. Vinculin antibody was used as loading control. D Densitiometric analysis of p66shc expression in esophageal squamous cell carcinoma (ESCC) and adenocarcinoma (EAC) as compared to adjacent normals (N). Columns, mean of fold increase in expression of four separate experiments, bars ± SE. * indicates stastically significant (p < 0.05) differences compared with adjacent normals as control using t test.

Back to article page