Simulation of LRA formation. The number of subspaces for L and the number of molecules were set as shown in the upper Table. The dissociation constants of LR (Kd1) and LRA (Kd2) are indicated in the Figure. The probabilities of LR and LRA formations were set to 0.67. L was added immediately before the 1.2 × 106th step (down arrow, 24 seconds). After the 1.5 × 107th step (upper arrow, 300 seconds), L was allowed to pass through the borders of the simulation box for L, except for the cell surface, and L was deleted in the outside area. Three simulation results are represented.