From: Leptin and Adiponectin: new players in the field of tumor cell and leukocyte migration
Molecule | Function/effect in general | Leukocyte function | References | Function and cancer type | References |
---|---|---|---|---|---|
Leptin | Satiety and appetite; signals to the brain to regulate energy homoeostasis and body weight. | Chemoattractant of neutrophils, monocytes & macrophages; stimulates chemokinesis of eosinophils | Promotes migration & invasion of chondrosarcoma, glioma, colon, endometrial prostate & hepatocellular carcinoma cells | ||
Adiponectin | Regulator of energy homoeostasis: enhances insulin sensitivity and glucose uptake; has anti-inflammatory properties. | Stimulates the migration of neutrophils & inhibits phagocytotic activity of macrophages. | [51] Figure 1 | Suppresses growth in breast, colon & prostate cancer cell lines Stimulates the migration of chondrosarcoma, colon & prostate carcinoma cells | Table 1 |