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Table 2 Summary of the general and specific function of adipocytokines

From: Leptin and Adiponectin: new players in the field of tumor cell and leukocyte migration

Molecule

Function/effect in general

Leukocyte function

References

Function and cancer type

References

Leptin

Satiety and appetite; signals to the brain to regulate energy homoeostasis and body weight.

Chemoattractant of neutrophils, monocytes & macrophages; stimulates chemokinesis of eosinophils

[18, 20–22]

Promotes migration & invasion of chondrosarcoma, glioma, colon, endometrial prostate & hepatocellular carcinoma cells

[28, 29, 34–38]

Adiponectin

Regulator of energy homoeostasis: enhances insulin sensitivity and glucose uptake; has anti-inflammatory properties.

Stimulates the migration of neutrophils & inhibits phagocytotic activity of macrophages.

[51]

Figure 1

Suppresses growth in breast, colon & prostate cancer cell lines

Stimulates the migration of chondrosarcoma, colon & prostate carcinoma cells

[62, 63, 67, 70, 71]

Table 1