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Table 1 Summary of the effects of leptin and adiponectin on migration and proliferation of various cancer cell lines

From: Leptin and Adiponectin: new players in the field of tumor cell and leukocyte migration

  Breast Carcinoma Cells Colon Carcinoma Cells
  MCF-7 MDA-MB-468 MDA-MB-231 SW480
Receptor expression
ObRI + + + +
AdipoR1 + + + +
AdipoR2 + + + +
Migration
Leptin no no no +
Adiponectin no no no +
Leptin+Adipo. no no no -
Proliferation
Leptin +19% +10% +44% +52%
Adiponectin +25% +18% +46% -31%
Leptin+Adipo. +16% +5% +61% +11%
  1. Receptor expression was determined using flow cytometry, migratory activity was investigated using our three-dimensional cell migration assay, and cell proliferation after 96 hours was evaluated using well-established XTT assay. All methods were performed as described previously [9].
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