From: Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?
Inhibitor peptide | Mode of action | IC50/Kd*/Ki** | References |
---|---|---|---|
CaN457-482-AID |  | 10 μMa | Perrino BA 1999 [167] |
mask the active centre of CaN | Â | Â | Â |
CaN424-521-AID |  | 2.5 μMa | Sagoo JK 1996 [164] |
mNFATc2106-121 - SPRIEIT |  | 12 μMi | Aramburu J 1998 [21] |
block CaN-NFATc interaction | Â | Â | Â |
VIVIT peptide |  | 0.5 μM* k < 1 μMl | Roehrl MH 2004 [114] Aramburu J 1999 [171] |
AKAP79330-357 | blocks CaN-NFATc interaction | 1.5 μMa | Dell'Acqua ML 2002 [173] |
RCAN1 | Â | 60 nM* k | Chan B 2005 [177] |
RCAN1-4141-197 - exon7 | block CaN-NFATc interaction | 70 nM* k | Chan B 2005 [177] |
RCAN1-4143-163 - CIC peptide |  | 1.25 μM* k | Mulero MC 2009 [111] |
LxVPc1 peptide | blocks CaN-NFATc interaction and modulates enzymatic activity of CaN | ~3 μMa | Rodriguez A 2009 [24] |
RCAN1-495-118 - SP repeat peptide | masks the active centre of CaN | 91.5 μM** a | Vega RB 2002 [185] |
VacA | inhibits translocation of NFATc | N.D. | Gebert B 2003 [187] |
A238L | Â | N.D. | Miskin JE 1998 [190] |
block CaN-NFATc interaction | Â | Â | Â |
A238L200-213 |  | 0.6 μMk | Miskin JE 2000 [194] |