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Figure 3 | Cell Communication and Signaling

Figure 3

From: Rac1 activation inhibits E-cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells

Figure 3

Rac1 influences the cell aggregation and cell migration of PANC-1 cells. Cell-cell adhesion of PANC-1 cells stably expressing EGFP, EGFP-Rac1(V12) or EGFP-Rac1(N17) was analysed by rotation aggregation assays. Cell migration was studied using uncoated transwell migration assays. The number of migrated cells in three randomly chosen visual fields (magnification 20×) is given. Cell migration through extracellular matrix was analysed using collagen type I-coated transwell inserts. Mean +/- SEM of three independent assays performed in duplicate is shown. Statistical differences were analysed compared to EGFP-expressing controls using the unpaired student t-test and (*) p < 0.05 was considered significant.

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