Figure 4
From: Function, regulation and pathological roles of the Gab/DOS docking proteins
(A) Simplified phylogenetic tree illustrating the emergence of PTK signaling systems and the emergence of Gab/Dos proteins. The tree is based on recent insights into metazoan evolution and highlights the position of the model organisms in which bona fide Gab/Dos proteins have been identified [137, 139, 140, 240, 241]. The distances between the individual clades do not represent phylogenetic or temporal distances. (B) Overall sequence similarity and sequence identity across the PH domains of the various Gab/DOS proteins discussed in this review.