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Figure 1 | Cell Communication and Signaling

Figure 1

From: Regulation of MicroRNA Biogenesis: A miRiad of mechanisms

Figure 1

Biogenesis of miRNAs and assembly into RISC complex. RNA pol II generates capped and polyadenylated pri-miRNAs which are processed by Drosha in the nucleus to generate pre-miRNAs. After translocation into the cytoplasm by exportin 5, pre-miRNAs are processed by Dicer to form the mature miRNA/miRNA* duplex. Following processing, miRNAs are assembled into the RISC complex. Only one strand of the duplex is stably associated with the RISC complex. The mature miRNA directs repression of mRNA containing partially complementary miRNA binding sites within the 3'UTR.

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