Skip to main content

Table 1 IRS expression in human cancer

From: Expression and function of the insulin receptor substrate proteins in cancer

Cancer Type IRS
Expression
Notes Ref(s)
Breast ↑ IRS-1 Well differentiated primary tumors [41, 43]
  ↑ IRS-1 Nuclear IRS-1 correlates with good prognosis [46]
  ↓ IRS-1 Poorly differentiated, high grade tumors [45, 46]
Hepatocellular ↑ IRS-1 mRNA/protein increased in HCC [38, 39]
  ↑ IRS-2 mRNA/protein increased in HCC [38, 39]
  ↑ IRS-4 mRNA increased in HCC [39]
Lung ↓ IRS-1 Larger (stage 1B) tumors, squamous cell carcinoma [47]
Medulloblastoma ↑ IRS-1 Co-localized with polyoma JCV T-antigen in nucleus [42]
Mesothelioma ↑ IRS-1 mRNA increased in malignant pleural mesothelioma [37]
  ↑ IRS-2 mRNA increased in malignant pleural mesothelioma [37]
Ovarian ↑ IRS-1 Protein increased in malignant epithelial tumors [44]
Pancreatic ↑ IRS-1 mRNA increased in 7/16 tumors [34]
  ↑ IRS-2 mRNA/protein increased in ductal-like cancer cells [35]
Prostate ↑ IRS-1 Protein increased in tumors and metastases [36]
  ↑ IRS-2 Protein correlates with increased Myc expression [40]
Renal ↑ IRS-2 mRNA increased in clear cell carcinomas [48]
  ↑ IRS-5 mRNA increased in clear cell carcinomas [48]