Table 1 Examples of cellular and extracellular stimuli that result in Crk-mediated signal transduction:
From: Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
Signals | Tyrosine phosphorylation connection | Biological outcome | References |
|---|---|---|---|
Cellular stimulation | Â | Â | Â |
v-Crk | p130Cas, pp110, paxillin | Cellular transformation | Mayer et al (1988) Matsuda et al (1990) |
v-Src | p130Cas, paxillin, others | Cellular transformation | Sakai et al (1994) |
Bcr-Abl | p130Cas, PI3-kinase | Cellular transformation, CML | Sattler et al (1996) |
Growth factor/Tyrosine kinase | Â | Â | Â |
NGF/TrkA | TrkA, p130Cas | Differentiation, neurite outgrowth | Hempstead et al (1994) Ribon et al (1996) |
EGF/Her proteins | Cbl, p130Cas, BRK | Proliferation, receptor internalization | Fukazawa et al (1996) Ojaniemi et al (1997) |
Insulin/IGF-1/IR/IGF-R | p130Cas, IRS-1, 4BS | Mitogenic Signaling | Beitner-Johnson et al (1996), Jin et al (2000) |
PDGF/PDGFRα | PDGF-Rα, p130Cas | Mitogenic Signaling | Anderson et al (1990), Yokote et al (1998) |
VEGF/VEGFR | p130Cas | Motility in endothelial cells, Angiogenesis | Salameh et al (2005) |
HGF/Met | Gab1, PI3-kinase | Epithelial morphogenesis | Garcia-Guzman et al (1999) |
Ephrin/EphB2 | p130Cas, Cbl | Membrane ruffling, tumor growth | Noren et al (2006) |
Cytokines/Receptors | Â | Â | Â |
IL-8/IL-8R | p130Cas | Cytoskeletal changes | Schraw et al (1995) |
IL-3/IL-3R; Epo-EpoR | Cbl | Proliferation | Barber at al (1997) |
Ang-2/Tie2 | p130Cas | Vascular smooth muscle cell migration | Takahashi et al (1998) |
Calcitonin-Calcitonin-R | p105CasL | Cytoskeletal changes | Zhang et al (1999) |
IL-2/IL2R | STAT-5 | Nuclear translocation/Transcription | Oda et al (2000) |
TGF-β/TGF-β1R | p130Cas | E-Cadherin cell to cell contact | Kim et al (2002) |
SLDF-1 | p130Cas./JAK2 | Cellular migration | Zhang et al (2001) |
Reelin/ApoER2 | Dab1 | Neuronal positioning | Chen et al (2004) |
Crosslinking TCR activation | p130Cas, Cbl, ZAP70 | Proliferation/Clonal expansion | Sawasdiksol et al (1995), Buday et al (1996) |
LFA/BCR activation | p130Cas, Cbl | B cell activation/differentiation | Petruzzelli et al (1996) |
LPA/Bombesin/RhoA | p130Cas, paxillin | Stress fiber formation/focal adhesions | Flinn et al (1996) |
GABA/m3 muscarinic-R | FAK, p130Cas | Exocytosis (pancreatic cells) | Rasado et al (2000) |
CCL20/CCR6 | p130Cas | Epithelial cell adhesion/migration | Yang et al (2005) |
Cell adhesion/Integrins/Mechanical force | Â | Â | Â |
FN/Integrin β1 | p130Cas/FAK | Cell adhesion and migration | Nojima et al (1996) Armulik et al (2000) |
uPA/uPAR | p130Cas | Motility in tumor cells | Smith et al (2008) |
MCSP/α4β1 integrin | p130Cas | Tumor invasion | Eisenmann et al (1999) |
Shear/Mechanical tension | p130Cas | Src activation/Focal adhesion remodeling | Okuda et al (1999), Sawada et al (2006) |
Col/Col-R | Paxillin | Cell Dispersion | Petit et al (2000) |
Osmotic Stress/Shock | Gab1, p130Cas | Stress responses | Gaul et al (2002) |
ECM proteins/Integrins | p130Cas | Rac1-mediated motility | Cho et al (2000) |
Laminin 10/11 | p130Cas | Cellular migration | Gu et al (2001) |
TIMP-2 | Paxillin | HVEC motility and invasion | Oh et al (2006) |
Chondroitin-Sul/Neuropilin | p130Cas | Axon guidance | Liu et al (2007) |
HLA | ERM proteins | Cell migration | Tsuda et al (2004) |
Particles | Â | Â | Â |
Apoptotic cells | p130Cas | Phagocytosis | Reddien et al (2000), Albert et al (2000) |
Molecular patterns/CD36 | p130Cas | Phagocytosis | Stuart et al (2007) |
Adenovirus/αvβ5 integrin | p130Cas | Virus endocytosis/trafficking | Li et al (2000) |
Yersinia | p130Cas | Pathogen uptake | Weidow et al (2000) |
Shigella | p130Cas/Abl | Bacterial uptake | Burton et al (2003) |
Listeria/InIB receptor | Gab1 | Bacterial Entry | Sun et al (2005) |
Helicobactor | CagA | Entry into Gastric cells | Suzuki et al (2005) |
Other | Â | Â | Â |
Fluoroaluminate | p130Cas | Spreading of pre-osteoblstic cells | Freitas et al (2002) |
Shingosine-1-phosphate | p130Cas | Gi-mediated motility | Ohmori et al (2001), Endo et al (2002) |
MFG-E8 | p130Cas | Phagocytosis | Akakura et al (2004), Hamayama et al (2002) |
Estrogen/Tamoxafin | Gab1, p130Cas | Non-genomic actions of E2 | Cabodi et al (2004), Cowell et al (2006) |