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Table 1 Examples of cellular and extracellular stimuli that result in Crk-mediated signal transduction:

From: Crk and CrkL adaptor proteins: networks for physiological and pathological signaling

Signals Tyrosine phosphorylation connection Biological outcome References
Cellular stimulation    
v-Crk p130Cas, pp110, paxillin Cellular transformation Mayer et al (1988) Matsuda et al (1990)
v-Src p130Cas, paxillin, others Cellular transformation Sakai et al (1994)
Bcr-Abl p130Cas, PI3-kinase Cellular transformation, CML Sattler et al (1996)
Growth factor/Tyrosine kinase    
NGF/TrkA TrkA, p130Cas Differentiation, neurite outgrowth Hempstead et al (1994) Ribon et al (1996)
EGF/Her proteins Cbl, p130Cas, BRK Proliferation, receptor internalization Fukazawa et al (1996) Ojaniemi et al (1997)
Insulin/IGF-1/IR/IGF-R p130Cas, IRS-1, 4BS Mitogenic Signaling Beitner-Johnson et al (1996), Jin et al (2000)
PDGF/PDGFRα PDGF-Rα, p130Cas Mitogenic Signaling Anderson et al (1990), Yokote et al (1998)
VEGF/VEGFR p130Cas Motility in endothelial cells, Angiogenesis Salameh et al (2005)
HGF/Met Gab1, PI3-kinase Epithelial morphogenesis Garcia-Guzman et al (1999)
Ephrin/EphB2 p130Cas, Cbl Membrane ruffling, tumor growth Noren et al (2006)
Cytokines/Receptors    
IL-8/IL-8R p130Cas Cytoskeletal changes Schraw et al (1995)
IL-3/IL-3R; Epo-EpoR Cbl Proliferation Barber at al (1997)
Ang-2/Tie2 p130Cas Vascular smooth muscle cell migration Takahashi et al (1998)
Calcitonin-Calcitonin-R p105CasL Cytoskeletal changes Zhang et al (1999)
IL-2/IL2R STAT-5 Nuclear translocation/Transcription Oda et al (2000)
TGF-β/TGF-β1R p130Cas E-Cadherin cell to cell contact Kim et al (2002)
SLDF-1 p130Cas./JAK2 Cellular migration Zhang et al (2001)
Reelin/ApoER2 Dab1 Neuronal positioning Chen et al (2004)
Crosslinking TCR activation p130Cas, Cbl, ZAP70 Proliferation/Clonal expansion Sawasdiksol et al (1995), Buday et al (1996)
LFA/BCR activation p130Cas, Cbl B cell activation/differentiation Petruzzelli et al (1996)
LPA/Bombesin/RhoA p130Cas, paxillin Stress fiber formation/focal adhesions Flinn et al (1996)
GABA/m3 muscarinic-R FAK, p130Cas Exocytosis (pancreatic cells) Rasado et al (2000)
CCL20/CCR6 p130Cas Epithelial cell adhesion/migration Yang et al (2005)
Cell adhesion/Integrins/Mechanical force    
FN/Integrin β1 p130Cas/FAK Cell adhesion and migration Nojima et al (1996) Armulik et al (2000)
uPA/uPAR p130Cas Motility in tumor cells Smith et al (2008)
MCSP/α4β1 integrin p130Cas Tumor invasion Eisenmann et al (1999)
Shear/Mechanical tension p130Cas Src activation/Focal adhesion remodeling Okuda et al (1999), Sawada et al (2006)
Col/Col-R Paxillin Cell Dispersion Petit et al (2000)
Osmotic Stress/Shock Gab1, p130Cas Stress responses Gaul et al (2002)
ECM proteins/Integrins p130Cas Rac1-mediated motility Cho et al (2000)
Laminin 10/11 p130Cas Cellular migration Gu et al (2001)
TIMP-2 Paxillin HVEC motility and invasion Oh et al (2006)
Chondroitin-Sul/Neuropilin p130Cas Axon guidance Liu et al (2007)
HLA ERM proteins Cell migration Tsuda et al (2004)
Particles    
Apoptotic cells p130Cas Phagocytosis Reddien et al (2000), Albert et al (2000)
Molecular patterns/CD36 p130Cas Phagocytosis Stuart et al (2007)
Adenovirus/αvβ5 integrin p130Cas Virus endocytosis/trafficking Li et al (2000)
Yersinia p130Cas Pathogen uptake Weidow et al (2000)
Shigella p130Cas/Abl Bacterial uptake Burton et al (2003)
Listeria/InIB receptor Gab1 Bacterial Entry Sun et al (2005)
Helicobactor CagA Entry into Gastric cells Suzuki et al (2005)
Other    
Fluoroaluminate p130Cas Spreading of pre-osteoblstic cells Freitas et al (2002)
Shingosine-1-phosphate p130Cas Gi-mediated motility Ohmori et al (2001), Endo et al (2002)
MFG-E8 p130Cas Phagocytosis Akakura et al (2004), Hamayama et al (2002)
Estrogen/Tamoxafin Gab1, p130Cas Non-genomic actions of E2 Cabodi et al (2004), Cowell et al (2006)
  1. The data are arranged in potential classes of initiating signals, as well as major tyrosine phosphorylated scaffolds that assemble with Crk or CrkL. For specific examples, please see references [2, 5, 1973] in the bibliography.