Figure 4
From: Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
The multiple fates of Crk and Abl interactions. Crk binding to the proline-rich region of Abl induces Abl transactivation (indicated by circle enclosing The (P). Subsequent to Abl activation following Crk binding, Abl phosphorylates Crk on Tyr-221, causing dissociation of the Abl and Crk complex. The fate of activated Abl is not known, but some studies indicate that activated Abl is ubiquitinated and degraded by the proteosomal pathway.