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Figure 3 | Cell Communication and Signaling

Figure 3

From: Crk and CrkL adaptor proteins: networks for physiological and pathological signaling

Figure 3

(A). Schematic structures of DOCK proteins. The SH3 domain, Docker Homology Region 1/CDM-Zizimin Homology1, Docker Homology Region 2/CDM Zizimin Homology 2, and Proline-rich sequences (shown in red) are indicated. The circular structure indicates the putative location of the Crk binding sites. Note that in DOCK5, Crk has been shown to bind to a non-canonical proline sequence. In DOCK2, Crk has been proposed to bind independent of proline. (B). Structure of the autoinhibited DOCK1/Crk complex. See text for details.

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