Table 2 Comparison of receptor-ligand pairs involved in the extravasation of tumor cells and leukocytes
From: Extravasation of leukocytes in comparison to tumor cells
| Â | Rolling | Adhesion | Diapedesis |
|---|---|---|---|
Tumor cells | PSGL-1 – E-selectin HCELL – E-selectin CD24 – E-selectin CEA – E/L-selectin N-cadherin – N-cadherin ICAM-1/LFA-1 mediated rolling via leukocytes | α4β1/β7 – VCAM CD44v6 – galectin-3 Lamp1/2 – galectin-3 αvβ3 – L1-CAM | N-cadherin – N-cadherin Apoptotic mechanisms |
Leukocytes | PSGL-1 – E-selectin HCELL – E-selectin CD24 – E-selectin L-selectin – peripheral lymph node adressin L-selectin – MadCAM N-cadherin – N-cadherin | LFA-1 – ICAM-1/2 Mac-1 – ICAM-1/2 LFA-1 – JAM-A Mac-1 – JAM-C VLA-1 – VCAM L1-CAM – VLA-5 glycosylated proteins – galectins | paracellular: JAM-C – JAM-B LFA-1 – JAM-A VLA-4 – JAM-B Mac-1 – JAM-C CD99 – CD99 PECAM-1 – PECAM-1 transcellular: LFA-1 – ICAM-1 PECAM-1 – PECAM-1 |