Table 8 Phosphatases (mouse) that have an FXFP motif and/or D-domain sequence. The number of potential MAPK phosphorylation sites, sequences fitting the optimal MAPK phosphorylation consensus sequence of PX(S/T)P, and FXFP motifs and D-domain sequences in phosphatases that use phosphatidylinositols or inositols as substrates are listed in the table; all sequences are for mouse proteins.
Isozyme | GenBank Accession # | # amino acids | # (S/T)P sites | Site(s) with the consensus PX(S/T)P sequence | FXFP motif | D-domain motif |
|---|---|---|---|---|---|---|
monophosphatase | ||||||
inositol monophosphatase A1 | O55023 | 277 | 2 | none | none | 261RIAKEIEI 261RIAKEIEIIPL |
3-phosphatase | ||||||
Myotubularin-related protein 1; MTMR1 | NP_058681 | 669 | 4 | none | none | 181KDMRNLRL |
PI(3,4,5)P3 3-phosphatase, PTEN | O08586 | 403 | 2 | none | 241FEFP | none |
4-phosphatase | ||||||
Inositol polyphosphate 4-phosphatase, Type Ia | NP_084542 | 939 | 7 | none | none | 147RHHRLHLTL |
SAC1 poly-phosphatidylinositol phosphatase | CAC20672 | 587 | 3 | none | none | 345KNMRWDRLSI 348RWDRLSILL 461RTGKRTQLGL 517RDWKFLAL 517RDWKFLALPI |
5-phosphatase | ||||||
Group II | ||||||
Inositol polyphosphate 5-phosphatase OCRL | NP_796189 | 900 | 2 | none | none | 445KLLKFDGLNI |
Synaptojanin 2 (synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2) | Q9D2G5 | 1434 | 15 | 987PVSP | none | 617RSHRYILL |
Sac-domain-containing inositol phosphatase 3 | NP_598760 | 907 | 5 | none | none | 663KFHRWEEEIDI |
Inositol polyphosphate 5-phosphatase, 75 kDa; Inositol polyphosphate 5-phosphatase B | NP_032411 | 993 | 5 | none | none | 31RQSRLLGL 420KFVRLVGIML |
Group III | ||||||
Inositol polyphosphate 5-phosphatase, 145 kDa; inositol polyphosphate 5-phosphatase D; SH2-containing inositol 5'-phosphatase 1; SHIP1 | NP_034696 | 1191 | 12 | 962PPTP 970PLSP | none | 352KSQKFLNKLVI |
Group IV | ||||||
PI polyphosphate 5-phosphatase type IV; Inositol polyphosphate 5-phosphatase E | Q9JII1 | 647 | 7 | 243PRSP | none | 83KLERTLSL 599RPGRDNIPL 611KFDRELYL 611KFDRELYLIGI |