Table 7 Phosphatases (human) that do not have an FXFP motif and/or D-domain sequence. Phosphatases that use phosphatidylinositols or inositols as substrates and do not contain an FXFP or D-domain sequence are listed in the table; all sequences are for human proteins. The number of potential MAPK phosphorylation sites and sequences fitting the optimal MAPK phosphorylation in these kinases are also identified.
Isozyme | GenBank Accession # | # amino acids | # (S/T)P sites | Site(s) with the consensus PX(S/T)P sequence |
|---|---|---|---|---|
inositol monophosphatase A2 | NP_055029 | 288 | 1 | none |
inositol monophosphatase A3 | NP_060283 | 359 | 3 | none |
Myotubularin; MTM1 | Q13496 | 603 | 3 | 586PTSP 589PSSP |
Myotubularin-related protein 2; MTMR2 | Q13614 | 643 | 4 | none |
Myotubularin-related protein 3; MTMR3 | Q13615 | 1198 | 9 | 582PTTP |
Myotubularin-related protein 6; MTMR6 | Q9Y217 | 621 | 3 | 559PESP |
Inositol polyphosphate 4-phosphatase, Type II | NP_003857 | 924 | 7 | 485PPSP |
Inositol 1,4,5-trisphosphate 5-phosphatase, Type I | Q14642 | 412 | 3 | none |
Synaptojanin 1 (synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | O43426 | 1575 | 23 | 1090PATP 1148PPSP 1161PKSP |
Sac-domain-containing inositol phosphatase 2 isoform 2; inositol polyphosphate 5-phosphatase F isoform 2 | NP_938144 | 500 | 8 | none |
Sac-domain-containing inositol phosphatase 2 isoform 3; inositol polyphosphate 5-phosphatase F isoform 3 | NP_938145 | 219 | 1 | none |
PI(4,5)P2 5-phosphatase A; PIB5PA; PIPP | Q15735 | 1006 | 26 | 148PRSP 199PSTP 345PRSP |
Skeletal muscle and kidney enriched inositol phosphatase isoform 1; SKIP 1 | NP_057616 | 448 | 4 | 283PDTP 356PSSP |
Skeletal muscle and kidney enriched inositol phosphatase isoform 2; SKIP 2 | NP_570122 | 372 | 4 | 207PDTP 280PSSP |
Phospholipids-inositol phosphatase; PTEN-like phosphatase; PLIP; PTPM1 | AAH20242 | 201 | 1 | none |
Inositol polyphosphate 5-phosphatase 2; SH2-containing inositol 5'-phosphatase 2; SHIP2 | JC5765 | 1258 | 7 | 156PSSP 163PETP 956PLTP 1001PPSP |