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Table 3 Kinases (mouse) that have an FXFP motif and/or D-domain sequence. The number of potential MAPK phosphorylation sites, sequences fitting the optimal MAPK phosphorylation consensus sequence of PX(S/T)P, and FXFP motifs and D-domain sequences in kinases that use phosphatidylinositols or inositols as substrates are listed in the table; all sequences are for mouse proteins.

From: Identification of mitogen-activated protein kinase docking sites in enzymes that metabolize phosphatidylinositols and inositol phosphates

Isozyme

GenBank Accession #

# amino acids

# (S/T)P sites

Site(s) with the consensus PX(S/T)P sequence

FXFP motif

D-domain motif

PI 3-kinase

Class I

PI 3-kinase α

NP_032865

1068

6

none

none

271KYIRSCIML

398RLARLCLSI

PI 3-kinase γ

NP_064668

1102

12

none

none

807KKKPLWL

Class II

PI 3-kinase, C2-α

NP_035213

1509

13

24PLTP

27PATP

1374PFSP

none

63KNGKARTDLEI

PI 3-kinase, C2-γ1

NP_997566

1506

12

none

none

930KDIKTCHLPL

1409KHLKNIHL

PI 3-kinase, C2-γ2

NP_035214

653

3

none

none

77KDIKTCHLPL

556KHLKNIHL

Class III

PI 3-kinase Vps34-type

NP_852079

887

4

none

none

656KLLRKENLDL

PI 4-kinase

PI 4-kinase α (PI4K230)

NP_001001983

2044

16

215PSSP

590PPSP

1822FVFP

15RRRDAVIAL

15RRRDAVIALGI

1340KRLREDISI

1340KRLREDISIMI

1429KRRTLLL

1429KRRTLLLSL

PI 4-kinase β (PI4K92)

NP_780565

801

8

none

none

232RGTKLRKLIL

333KTQRLISELSL

581KPYKILVI

PI 4-kinase type II (PI4K55)

NP_663476

479

5

49PCSP

none

435KDNKSPLHL

PIP kinase

Type I PIPK (PI4P 5-kinase)

PI4P 5-kinase, type Iα

NP_032872

539

3

464PSTP

none

335KSHRGEKLLL

PI4P 5-kinase type Iβ

NP_032873

546

5

498PQTP

none

374RNNKGERLLL

377KGERLLLYI

377KGERLLLYIGI

PI4P 5-kinase type Iγ

NP_032870

661

5

509PCTP

none

386RGERLLLHI

386RGERLLLHIGI

Type III PIPK (PIKfyve; PI3P 5-kinase)

PIKfyve

NP_035216

2052

31

18PRSP

21PASP

32PLTP

262PRTP

536PFTP

1479PPSP

none

270KASRNIFL

655KNPKILLL

1935KMVRDNPLYI