Isozyme | GenBank Accession # | # amino acids | # (S/T)P sites | Site(s) with the consensus PX(S/T)P sequence | FXFP motif | D-domain motif |
---|---|---|---|---|---|---|
PI 3-kinase | ||||||
Class I | ||||||
PI 3-kinase α | NP_032865 | 1068 | 6 | none | none | 271KYIRSCIML 398RLARLCLSI |
PI 3-kinase γ | NP_064668 | 1102 | 12 | none | none | 807KKKPLWL |
Class II | ||||||
PI 3-kinase, C2-α | NP_035213 | 1509 | 13 | 24PLTP 27PATP 1374PFSP | none | 63KNGKARTDLEI |
PI 3-kinase, C2-γ1 | NP_997566 | 1506 | 12 | none | none | 930KDIKTCHLPL 1409KHLKNIHL |
PI 3-kinase, C2-γ2 | NP_035214 | 653 | 3 | none | none | 77KDIKTCHLPL 556KHLKNIHL |
Class III | ||||||
PI 3-kinase Vps34-type | NP_852079 | 887 | 4 | none | none | 656KLLRKENLDL |
PI 4-kinase | ||||||
PI 4-kinase α (PI4K230) | NP_001001983 | 2044 | 16 | 215PSSP 590PPSP | 1822FVFP | 15RRRDAVIAL 15RRRDAVIALGI 1340KRLREDISI 1340KRLREDISIMI 1429KRRTLLL 1429KRRTLLLSL |
PI 4-kinase β (PI4K92) | NP_780565 | 801 | 8 | none | none | 232RGTKLRKLIL 333KTQRLISELSL 581KPYKILVI |
PI 4-kinase type II (PI4K55) | NP_663476 | 479 | 5 | 49PCSP | none | 435KDNKSPLHL |
PIP kinase | ||||||
Type I PIPK (PI4P 5-kinase) | ||||||
PI4P 5-kinase, type Iα | NP_032872 | 539 | 3 | 464PSTP | none | 335KSHRGEKLLL |
PI4P 5-kinase type Iβ | NP_032873 | 546 | 5 | 498PQTP | none | 374RNNKGERLLL 377KGERLLLYI 377KGERLLLYIGI |
PI4P 5-kinase type Iγ | NP_032870 | 661 | 5 | 509PCTP | none | 386RGERLLLHI 386RGERLLLHIGI |
Type III PIPK (PIKfyve; PI3P 5-kinase) | ||||||
PIKfyve | NP_035216 | 2052 | 31 | 18PRSP 21PASP 32PLTP 262PRTP 536PFTP 1479PPSP | none | 270KASRNIFL 655KNPKILLL 1935KMVRDNPLYI |