Table 1 Kinases (human) that have an FXFP motif and/or D-domain sequence. The number of potential MAPK phosphorylation sites, sequences fitting the optimal MAPK phosphorylation consensus sequence of PX(S/T)P, and FXFP motifs and D-domain sequences in kinases that use phosphatidylinositols or inositols as substrates are listed in the table; all sequences are for human proteins.
Isozyme | GenBank Accession # | # amino acids | number of (S/T)P sites | Site(s) with the consensus PX(S/T)P sequence | FXFP motif | D-domain motif |
|---|---|---|---|---|---|---|
PI 3-kinase | ||||||
Class I | ||||||
PI 3-kinase α | P42336 | 1068 | 6 | none | none | 271KYIRSCIML 398RAARLCLSI |
PI 3-kinase γ | P48736 | 1101 | 13 | none | none | 806KKKPLWL |
PI 3-kinase δ | NP_005017 | 1044 | 4 | none | 585FSFP | none |
Class II | ||||||
PI 3-kinase C2-α | NP_002636 | 1686 | 16 | 118PVTP 199PLTP 202PATP | none | 238KNGKARTDLEI |
PI 3-kinase, C2-γ | CAA03853 | 1448 | 9 | none | none | 400KVSRQCLLTL 830KEQKLIKI 1327KKPKVQLVI 1347KHMKNIHL |
Class III | ||||||
PI 3-kinase Vps34-type | S57219 | 887 | 6 | none | none | 656KLLRKENLDL |
PI 4-kinase | ||||||
PI 4-kinase α (PI4K230) | P42356 | 2044 | 16 | 215PSSP 590PPSP | 1822FVFP | 15RRRDAVIAL 15RRRDAVIALGI 1340KRLREDISI 1340KRLREDISIMI 1429KRRTLLL 1429KRRTLLLSL |
PI 4-kinase β (PI4K92) | NP_002642 | 828 | 7 | none | none | 244RGTKLRKLIL 360KTQRLISELSL 608KPYKILVI |
PI 4-kinase type II (PI4K55) | NP_060895 | 479 | 5 | 49PGSP | none | 435KDNKSPLHL |
PI 4-kinase type II-β (PI4K55) | NP_060793 | 481 | 3 | none | none | 239KVGRKFHRIGL |
PIP kinase | ||||||
Type I PIPK (PI4P 5-kinase) | ||||||
PI4P 5-kinase, type Iα | NO_003548 | 549 | 3 | 501PQTP | none | 376RNSKGERLLL 379KGERLLLYI 379KGERLLLYIGI |
PI4P 5-kinase, type Iβ | NP_003549 | 540 | 4 | 464PSTP | none | 335KSHRGEKLLL |
PI4P 5-kinase type Iγ | NP_036530 | 668 | 6 | 510PCTP | none | 386RGERLLLHI 386RGERLLLHIGI |
Type III PIPK (PIKfyve; PI3P 5-kinase) | ||||||
PIKfyve | Q9Y2I7 | 2098 | 32 | 18PRSP 21PTSP 32PLTP 251PRTP 581PFTP 1524PPSP | none | 259KASRNIFL 700KNPKILLL 1981KMVRDNPLYI |
Ins(1,4,5)P 3 3-kinase | ||||||
Ins(1,4,5)P3 3-kinase B | P27987 | 946 | 24 | 69PRSP 164PRSP 262PASP | 56FLFP | 665KKKYPWIQL |
Ins(1,3,4,5,6) 5 2-kinase | ||||||
Ins(1,3,4,5,6)5 2-kinase | AAM75353 | 491 | 5 | none | 240FFFP | none |