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Figure 5 | Cell Communication and Signaling

Figure 5

From: Platelet-derived growth factor modulates rat vascular smooth muscle cell responses on laminin-5 via mitogen-activated protein kinase-sensitive pathways

Figure 5

Integrins and growth factors activate intracellular signaling cascades in rVSMC. Intracellular signaling pathways that converge through MEK and ERK activation, may be initiated in rVSMC by the addition of PDGF-BB, as well as binding to laminin-5 or fibronectin. The MEK1 inhibitor PD98059 blocks MEK1 activation and alters rVSMC responses to PDGF-BB on laminin-5, but not fibronectin. The addition of TGF-β1, which may block later events in the cell cycle, is sufficient to block PDGF-BB induced responses of rVSMC on both laminin-5 and fibronectin.

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