Figure 1From: Platelet-derived growth factor modulates rat vascular smooth muscle cell responses on laminin-5 via mitogen-activated protein kinase-sensitive pathwaysPDGF-BB increased rVSMC migration on laminin-5 in vitro . The addition of PDGF-BB increased rVSMC migration on laminin-5, in a dose-dependent manner, over rVSMC haptotactic migration induced by the presence of laminin-5. rVSMC migration on laminin-5 was inhibited by both PD98059 (MEK1 inhibitor) and TGF-β1, in a dose-dependent manner.Back to article page