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Figure 3 | Cell Communication and Signaling

Figure 3

From: Xenopus frizzled-4S, a splicing variant of Xfz4 is a context-dependent activator and inhibitor of Wnt/β-catenin signaling

Figure 3

Extracellular domain of Xfz8 (ECD8) can activate Wnt/β-catenin pathway in combination with Xwnt-5a. (A) 500 pg/embryo ECD8 mRNA when injected in conjunction with Xwnt-5a (50 pg/embryo), Xnr3 expression was induced in animal cap tissues. Extracellular domains of Xfz7 (ECD7, 300 pg/embryo) or Hfz5 (ECD5, 500 pg/embryo) did not synergize with Xwnt-5a in inducing Xnr3 expression. (B) ECD8 (200 pg/embryo) and Wnt-5a (50 pg/embryo) when injected into the ventral marginal zone, Xnr3 expression was induced. (C) At later stages these embryos developed partial secondary axis without head structures. No secondary axes were observed when ECD8 or Wnt-5a was injected alone.

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Cell Communication and Signaling

ISSN: 1478-811X