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Table 3 JNK stimulating agents in prostatic cells

From: Mitogen Activated Protein kinase signal transduction pathways in the prostate

Agent Cell line Apoptosis Ref
NDF/Heregulin LNCaP ? 81
TGF-b DU145, PC3 ? 107,108
2-methoxyestradiol (2-ME) LNCaP, PC3, Dunning Rat Model Suggested 109
N-(4-hydroxyphenyl)retinamide (4-HPR) LNCaP + 49,50,57
Anisomycin (translation inhibitor) DU145, PC3 + 62,71
Cryptophycin-52 (antimicrotubule agent) LNCaP, DU145 + 110
Tumor necrosis factor (TNF) LNCaP (mild), DU145 ? 70
Grape seed extract DU145 + 102
Selenite DU145 ? 104
Zinc DU145, PC3 ? 111
Methionine restriction PC3 + 112
Phorbol esters LNCaP ? 113
Thapsigargin LNCaP ? 113
Arsenic trioxide DU145, PC3 - 114
PEITC LNCaP + 68