Table 3 JNK stimulating agents in prostatic cells
From: Mitogen Activated Protein kinase signal transduction pathways in the prostate
Agent | Cell line | Apoptosis | Ref |
|---|---|---|---|
NDF/Heregulin | LNCaP | ? | 81 |
TGF-b | DU145, PC3 | ? | 107,108 |
2-methoxyestradiol (2-ME) | LNCaP, PC3, Dunning Rat Model | Suggested | 109 |
N-(4-hydroxyphenyl)retinamide (4-HPR) | LNCaP | + | 49,50,57 |
Anisomycin (translation inhibitor) | DU145, PC3 | + | 62,71 |
Cryptophycin-52 (antimicrotubule agent) | LNCaP, DU145 | + | 110 |
Tumor necrosis factor (TNF) | LNCaP (mild), DU145 | ? | 70 |
Grape seed extract | DU145 | + | 102 |
Selenite | DU145 | ? | 104 |
Zinc | DU145, PC3 | ? | 111 |
Methionine restriction | PC3 | + | 112 |
Phorbol esters | LNCaP | ? | 113 |
Thapsigargin | LNCaP | ? | 113 |
Arsenic trioxide | DU145, PC3 | - | 114 |
PEITC | LNCaP | + | 68 |