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Table 1 p42/p44 MAP kinase Activating agents in Prostatic cells

From: Mitogen Activated Protein kinase signal transduction pathways in the prostate

Agent Cell line Cell effect Ref
Endogenous    
Epidermal-derived growth factor (EGF) LNCaP, DU145, PC3 Proliferation 8,9,89,90
Transforming growth factor (TGF)-α PC3 Proliferation 91
Insulin-like growth factor (IGF) LNCaP, DU145, LAPC-4, PC3 Proliferation 89,92
Fibroblast-derived growth factors (FGF) LNCaP Growth 93
Interluekin (IL)-6 LNCaP ? 12,94
Neu differentiation factor (NDF)/Heregulin LNCaP ? 81
Lysophosphatidic acid (LPA) DU145, PC3 Proliferation 9,95
Bombesin DU145, PC3 Proliferation 22,95
Bradykinin PC3 Proliferation 96
Epinephrine LNCaP NE diff (?) 94
Adenosine triphosphate tumor spheroids ? 97
Vitamin D LNCaP ? 47
5-HETE PC3 Proliferation 26
13-(S)-HODE PC3 ? 38
Nitric oxide (NO) LNCaP, PC3 ? 37
Androgens    
Testosterone LNCaP Survival 50
Dihydrotestosterone (DHT)* Primary prostate stromal, LNCaP ? 10
Hydroxyflutamide (antiandrogen) DU145, PC3AR2, CWR22 ? 98
Exogenous    
Heat PC3 ? 33
Hypoxia LNCaP, PC3 ? 37
ionizing radiation DU145 Survival 53
Resveratrol (stilbene) DU145 Apoptosis 45
Phenylethyl isothiocyanate (PEITC) PC3 Apoptosis 46
DDT (pesticide) LNCaP ? 99
  1. 1 *not supported by other studies.