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Figure 10 | Cell Communication and Signaling

Figure 10

From: Cyclosporin A differentially inhibits multiple steps in VEGF induced angiogenesis in human microvascular endothelial cells through altered intracellular signaling

Figure 10

Effect of VEGF on Nuclear Factor of Activated Tcells (NFAT) activation in HIMEC. VEGF stimulation of HIMEC leads to dephosphorylation of NFATp and its nuclear translocation from the cytosol as detected by western blot analysis using specific anti-NFAT antibodies. Stimulation of HIMEC with 50 ng/ml VEGF resulted in a complete NFATp translocation to the nucleus within 15 min which was sustained for 2 hr. Nuclear NFATp declined to undetectable levels after 5 hr.

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