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Figure 1 | Cell Communication and Signaling

Figure 1

From: Neuronal and astrocytic interactions modulate brain endothelial properties during metabolic stresses of in vitro cerebral ischemia

Figure 1

Differential effects of metabolic stresses on brain endothelial, neurovascular and gliovascular barriers. A) Brain endothelial barrier. Significant differences were observed between normal and OGDR brain endothelial barrier at 4d. B. Neurovascular barrier. Significant differences between aglycemic, hypoxic and OGDR treated neurovascular barrier was observed from 1d until 5d compared to untreated neurovascular barrier. C. Gliovascular barrier. While no significant differences between untreated and hypoxic gliovascular barrier were observed, aglycemic and OGDR gliovascular barrier was significantly different from untreated from 1d to 3d. D. Comparison of untreated brain endothelial, neurovascular and gliovascular barriers. No significant differences between brain endothelial, neurovascular and gliovascular barriers were observed until 2d. However, neurovascular barrier was significantly lower compared to brain endothelial barrier until 4d and gliovascular barrier was significantly lower until 5d. E. Comparison of aglycemic brain endothelial, neurovascular and gliovascular barriers. No significant differences between aglycemic brain endothelial and neurovascular barriers were observed. However, significant increase in aglycemic gliovascular barrier was observed until 3d. Aglycemic gliovascular barrier was significantly lower at 4d and 5d compared to aglycemic brain endothelial barrier. F. Comparison of Hypoxic brain endothelial, neurovascular and gliovascular barriers. While hypoxic neurovascular barrier was significantly lower than hypoxic brain endothelial barrier from 3d, hypoxic gliovascular barrier was significantly lower from 1d until 5d. G. Comparison of OGDR brain endothelial, neurovascular and gliovascular barriers. Both OGDR neurovascular and gliovascular barriers showed a significant increase compared to OGDR brain endothelial barrier until 3d. However, at 4d OGDR gliovascular barrier was significantly lower compared to OGDR brain endothelial and neurovascular barriers. Repeated measures ANOVA from 0h baseline. Values are expressed in percent baseline at 0h ± SEM. Un-paired t-test was used to check significance between groups at the same time point. # P<0.05 is considered significantly different from respective controls at the same time point.

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