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Table 1 Metabolic paramaters of Ad-GFP and Ad-FTO mice after an overnight fasting

From: FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver

  Ad-GFP mice Ad-FTO mice p value
Body weight (g) 22.5 ± 0.5 23.8 ± 0.5 NS
Liver weight (g) 1.6 ± 0.06 1.5 ± 0.06 NS
Fasting glycemia (mg/dl) 86 ± 5 110 ± 3 0.002
Fasting insulinemia (ng/ml) 0.22 ± 0.03 0.50 ± 0.01 0.02
Fasting leptinemia (ng/ml) 0.5 ± 0.1 13 ± 0.3 0.03
  1. FTO was overexpressed in liver of mice by adenoviral infection using a recombinant adenovirus encoding human FTO or GFP (as control) proteins for 10 days (2.108ifu/g of body weight). Blood was removed by reorbital punction on isofluran-anesthesized mice, after an overnight fasting. Data are means ± SEM (n = 8/group).