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Figure 7 | Cell Communication and Signaling

Figure 7

From: FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver

Figure 7

FTO overexpression in liver of mice affects leptin action and glucose homeostasis. Liver of mice were infected with recombinant adenovirus encoding human FTO or GFP (control) proteins for 10 days (2.108ifu/g of body weight). A) After an overnight fasting, infected mice were treated by ip injection with leptin (1 μg/g) for 30 minutes. Representative Western blots and quantitative analysis of pPKB(S473) and PKB proteins in liver of leptin-treated infected mice. Note that four parts of a same gel were shown. B) Glucose tolerance test performed after 6 hours of fasting on infected mice and corresponding quantitative analysis of area under curves. B) Insulin tolerance test performed after 6 hours of fasting on infected mice and corresponding quantitative analysis of area under curves. Data are means ± SEM (n = 3/group for A and n = 8/group for B-C). *p < 0.05 compared to GFP infected mice.

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