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Figure 2 | Cell Communication and Signaling

Figure 2

From: FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver

Figure 2

IL-6 regulates STAT3 signaling and FTO expression in HuH7 cells. HuH7 cells were depleted for 16 hours of serum and treated with IL-6 (10 ng/ml) during different times. A) Representative Western blots and quantitative analysis of Y705 phosphorylation of STAT3 in HuH-7 cells treated with IL-6 (10 ng/ml), showing that IL-6 stimulates tyrosine phosphorylation of STA3 in a time-dependant manner in HuH7 cells expressing LepRb. B) Representative Western blots and quantitative analysis of FTO expression in HuH7 cells treated with IL-6, showing that IL-6 stimulates FTO protein levels in HuH7 cells expressing LepRb. Data are means ± SEM (n = 4/group).*p < 0.05 compared to untreated cells.

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