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Table 2 Physiological functions of NR2F family members and their roles in disease

From: Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions

  NR2F1 NR2F2 NR2F6
Immune system Autoimmunity, expressed CD4+/CD8+and CD19+cells[26, 49] Autoimmunity, expressed CD4+/CD8+and CD19+cells[26, 50, 51] T cell development, activation thresholds, CD4+Th17 autoimmunity, leukemia[51, 53, 54, 57, 64, 98]
T cells[27], + + +++
B cells[27], + + +++
Development Embryo, eye, hair, ear, angiogenesis [99] ES cell differentiation, mesenchyme, angiogenesis, vessel identity, cerebellum, lymphangiogenesis, stomach, eye, osteoblast [34, 100102]  
Hormone regulation LHβ, Vegf, LH, receptor, RAR [103]   LH receptor, oxytocin [2224, 104]
Cancer   Breast & prostate cancer, MC-lymphoma, metastasis, AML [43, 105] Colorectal, survival [25, 52, 54, 106]
Metabolism Lipid uptake [41, 103] Insulin secretion, adipogenesis, energy metabolism Lipid metabolism [107, 108]
CNS Axons formation [109] Circadian rhythm, nociception [19, 110112]
Cortex patterning
Fate specification
Kidney   Renin production Renin production [20, 21, 113]
Reproduction   Reproduction  
  1. The expression pattern of the Nr2f gene family has been investigated in resting and activated T and B cells by the ImmGen Consortium ( All Nr2f family members are expressed in diverse adaptive and innate immune cells. Of note, and as a general rule of thumb, the mRNA expression levels of Nr2f6 in hematopoietic cells are increased approximately twofold in comparison to the mRNA expression levels of Nr2f1 and Nr2f2 dipicted as + versus +++. Nr2f1 and Nr2f2 in non-hematopoietic tissues were reviewed recently [16], therefore, only new and immune relevant references, as well as those for Nr2f6, are shown.