Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions

Table 2 Physiological functions of NR2F family members and their roles in disease

	NR2F1	NR2F2	NR2F6
Immune system	Autoimmunity, expressed CD4⁺/CD8⁺and CD19⁺cells[26, 49]	Autoimmunity, expressed CD4⁺/CD8⁺and CD19⁺cells[26, 50, 51]	T cell development, activation thresholds, CD4⁺Th17 autoimmunity, leukemia[51, 53, 54, 57, 64, 98]
T cells[27], http://www.immgen.org	+	+	+++
B cells[27], http://www.immgen.org	+	+	+++
Development	Embryo, eye, hair, ear, angiogenesis [99]	ES cell differentiation, mesenchyme, angiogenesis, vessel identity, cerebellum, lymphangiogenesis, stomach, eye, osteoblast [34, 100–102]
Hormone regulation	LHβ, Vegf, LH, receptor, RAR [103]		LH receptor, oxytocin [22–24, 104]
Cancer		Breast & prostate cancer, MC-lymphoma, metastasis, AML [43, 105]	Colorectal, survival [25, 52, 54, 106]
Metabolism	Lipid uptake [41, 103]	Insulin secretion, adipogenesis, energy metabolism	Lipid metabolism [107, 108]
CNS	Axons formation	[109]	Circadian rhythm, nociception [19, 110–112]
	Cortex patterning
	Fate specification
Kidney		Renin production	Renin production [20, 21, 113]
Reproduction		Reproduction

The expression pattern of the Nr2f gene family has been investigated in resting and activated T and B cells by the ImmGen Consortium (http://www.immgen.org). All Nr2f family members are expressed in diverse adaptive and innate immune cells. Of note, and as a general rule of thumb, the mRNA expression levels of Nr2f6 in hematopoietic cells are increased approximately twofold in comparison to the mRNA expression levels of Nr2f1 and Nr2f2 dipicted as + versus +++. Nr2f1 and Nr2f2 in non-hematopoietic tissues were reviewed recently [16], therefore, only new and immune relevant references, as well as those for Nr2f6, are shown.

ISSN: 1478-811X