Table 1 Parameter values
Name | Unit | Set1 | Set2 | Set3 | Set4 | Set5 | Set6 | Set7 |
|---|---|---|---|---|---|---|---|---|
Fixed parameters | ||||||||
N A | molecules/mole | 6.02E+23 | 6.02E+23 | 6.02E+23 | 6.02E+23 | 6.02E+23 | 6.02E+23 | 6.02E+23 |
V shell | liter | 4.85E-15 | 4.85E-15 | 4.85E-15 | 4.85E-15 | 4.85E-15 | 4.85E-15 | 4.85E-15 |
N cell | cells | 4.00E+04 | 4.00E+04 | 4.00E+04 | 4.00E+04 | 4.00E+04 | 4.00E+04 | 4.00E+04 |
V fluid | liter | 1.24E-04 | 1.24E-04 | 1.24E-04 | 1.24E-04 | 1.24E-04 | 1.24E-04 | 1.24E-04 |
FGFR | molecules/cell | 2.00E+04 | 2.00E+04 | 2.00E+04 | 2.00E+04 | 2.00E+04 | 2.00E+04 | 2.00E+04 |
Fitted parameters | ||||||||
HSGAG | molecules/cell | 1.00E+05 | 1.00E+05 | 1.27E+05 | 1.00E+05 | 1.00E+05 | 1.00E+05 | 1.00E+05 |
FRS2 | molecules/cell | 1.00E+04 | 5.27E+05 | 4.37E+04 | 1.00E+04 | 1.00E+04 | 1.16E+04 | 1.02E+04 |
MEK | molecules/cell | 1.00E+06 | 7.24E+05 | 3.08E+05 | 3.20E+05 | 3.73E+05 | 1.55E+05 | 3.66E+05 |
ERK | molecules/cell | 1.30E+06 | 1.52E+06 | 1.34E+06 | 1.88E+06 | 4.93E+06 | 1.09E+06 | 3.61E+06 |
k f0 | 1/((molecule/cell)*s) | 2.67E-08 | 1.10E-08 | 8.61E-09 | 1.97E-08 | 1.46E-08 | 1.52E-08 | 2.60E-08 |
k r0 | 1/s | 1.94E-03 | 8.00E-04 | 6.29E-04 | 1.44E-03 | 1.07E-03 | 1.11E-03 | 1.95E-03 |
k f1a | 1/((molecule/cell)*s) | 7.89E-10 | 1.13E-09 | 3.14E-09 | 9.28E-10 | 1.32E-09 | 2.04E-09 | 2.37E-09 |
k r1a | 1/s | 9.17E-05 | 1.31E-04 | 3.63E-04 | 1.07E-04 | 1.52E-04 | 2.36E-04 | 2.75E-04 |
k f5a | 1/((molecule/cell)*s) | 8.62E-09 | 1.72E-08 | 2.47E-08 | 5.65E-09 | 1.19E-08 | 6.57E-08 | 3.10E-06 |
k r5a | 1/s | 2.60E-07 | 1.27E-03 | 1.90E-04 | 3.03E-08 | 2.84E-06 | 3.24E-07 | 2.14E-01 |
k fdim | 1/((molecule/cell)*s) | 8.48E-02 | 1.50E-01 | 2.05E-03 | 1.30E-01 | 2.01E-02 | 5.26E-02 | 3.87E-06 |
k rdim | 1/s | 9.94E+00 | 1.00E-05 | 2.90E-04 | 1.92E-04 | 1.09E-01 | 5.83E-04 | 1.35E-02 |
k fph | 1/s | 3.30E+00 | 4.92E-01 | 1.58E-02 | 5.36E+00 | 2.49E-01 | 5.02E-02 | 2.08E-03 |
k fint1 | 1/s | 1.38E-04 | 2.14E-03 | 1.00E-06 | 9.53E-05 | 9.90E-06 | 4.38E-04 | 2.45E-05 |
k rint1 | 1/s | 4.70E-07 | 4.26E-04 | 2.52E-03 | 2.31E-07 | 2.42E-03 | 9.73E-08 | 9.03E-04 |
k f15 | 1/((molecule/cell)*s) | 2.41E-04 | 4.61E-04 | 5.86E-04 | 2.09E-04 | 2.14E-04 | 4.43E-04 | 1.73E-04 |
k r15 | 1/s | 4.21E-03 | 4.87E-06 | 3.40E-03 | 1.66E-04 | 2.11E-02 | 8.33E-05 | 1.20E-05 |
k f19 | 1/s | 4.72E-01 | 5.47E-01 | 5.88E+00 | 3.95E+00 | 1.00E+01 | 5.50E-01 | 9.03E+00 |
k f35 | 1/((molecule/cell)*s) | 3.58E-04 | 5.43E-04 | 1.48E-04 | 1.47E-04 | 9.23E-05 | 1.40E-04 | 5.80E-05 |
k r35 | 1/s | 2.34E-01 | 1.13E-01 | 5.24E-05 | 2.74E-02 | 2.00E-03 | 4.15E-06 | 1.70E-05 |
k f36 | 1/s | 3.04E-01 | 2.34E-01 | 5.53E-02 | 1.33E-02 | 2.57E-02 | 4.08E-02 | 3.78E-02 |
k f39 | 1/((molecule/cell)*s) | 2.61E-05 | 4.14E-08 | 3.28E-07 | 8.15E-06 | 1.00E-03 | 8.73E-05 | 5.78E-06 |
k r39 | 1/s | 1.66E-06 | 4.91E-06 | 6.60E-05 | 3.94E-05 | 2.99E-01 | 3.55E-04 | 1.04E-04 |
k f40 | 1/s | 9.95E-02 | 2.62E-01 | 1.11E-01 | 1.74E+00 | 1.51E+00 | 1.71E-01 | 1.04E+00 |
k fdp1 | 1/s | 4.71E+00 | 6.65E+00 | 4.29E+00 | 9.96E+00 | 1.00E+01 | 5.43E+00 | 5.45E+00 |
k fdp2 | 1/s | 1.03E+00 | 8.93E-03 | 1.83E-02 | 3.10E-02 | 8.29E+00 | 1.78E+00 | 6.56E-02 |
k fdp3 | 1/s | 1.28E+00 | 6.37E-03 | 5.71E-03 | 4.66E-03 | 4.64E-03 | 5.07E-03 | 1.51E-02 |
k f43 | 1/((molecule/cell)*s) | 1.06E-04 | 9.66E-06 | 3.08E-06 | 3.13E-07 | 1.53E-07 | 8.09E-07 | 3.92E-07 |
k r43 | 1/s | 3.34E-05 | 7.34E-01 | 5.43E-01 | 1.71E-04 | 1.71E-04 | 2.21E-02 | 8.90E-05 |
k f44 | 1/s | 2.14E-04 | 4.28E-02 | 2.10E-01 | 4.39E-04 | 3.91E-04 | 3.05E+00 | 3.05E-04 |
k f47 | 1/s | 3.36E+00 | 2.32E-04 | 9.67E-05 | 2.10E-05 | 2.01E-05 | 1.52E-04 | 8.06E-02 |
k r47 | 1/s | 1.47E-02 | 8.25E-05 | 6.01E-07 | 1.15E-07 | 9.96E-02 | 5.54E-06 | 4.00E-02 |