Figure 3From: Deciphering the mechanism behind Fibroblast Growth Factor (FGF) induced biphasic signal-response profilesSchematic of the FGFR signaling pathway. Based on published surface plasmon resonance data, we assume that FGF binds first to HSGAG before it binds to the receptor. The Ras-Raf signaling cascade is reduced to a two-step cascade to increase model identifiability. The model also accounts for negative feedback from pERK to FRS2 and nuclear localization of pERK.Back to article page