Figure 2

Mathematical model for pERK response to FGF2: the mathematical model explains the dynamics of pERK response to FGF2 concentrations varying over three orders of magnitude. Experimental results are plotted as circles with standard deviations and model fits are plotted as solid lines. A). Feature-based constraints for fitting the mathematical model to pERK dose response data. B). Dynamics of pERK response to varying levels of FGF2-ligand (0.16 ng/ml to 500 ng/ml). pERK is measured at 1,2,3,4,5,8,10,20,30,60 and 120 min post ligand stimulation. C). pERK dose response curves at 5, 20 and 60 min post ligand stimulation.