Table 2 miR-125b associated with tumor suppressive signaling in cancer

Down

E2F3

Regulator of colony formation, cell division

[49]

Down

MMP13

Regulator of cell migration and invasion

[50]

Down

NA

NA

[51]

Down

EPO, EPOR

Regulator of differentiation and survival of erythroid cells

[52]

Down

ETS1

Regulator of cell proliferation, clonogenicity and cell cycle progression

[24]

Down

ENPEP, CK2-α, CCNJ, MEGF9

Cell proliferation and anchorage-independent growth

[53]

Down

ERBB2/ERBB3

Regulator of migration and invasion

[40]

Down

MUC1

Regulator of proliferation and apoptosis induction

[54]

Down

ERBB2

Regulator of cell invasion

[20]

Down

IGF1, IGFR, mTOR, RSK1

Growth inhibitory properties

[55]

Down

PI3K/Akt/mTOR

Regulator of proliferation, migration and invasion

[56]

Down

TACSTD2 (TROP2)

Causes mitogen-activated protein kinase pathway dysfunction

[17]

Down

Bcl-W, Mcl-1, IL-6R

Regulator of apoptosis

[57, 58]

Down

BCL2

Regulator of apoptosis

[59]

Down

PIGF

Regulator of invasion/angiogenesis

[60]

Down

LIN28B

Regulator of cell migration and invasion

[61]

Down

Suppresses the cell growth via Akt phosphorylation

[62]

Higher in HCCs with good survival

Down

NA

Regulator of proliferation

[21]

Down

STAT3

Regulator of proliferation and migration

[22]

Down

BCL3

Regulator of proliferation and clonal formation

[63]

Down

HER2/HER3

Regulator of proliferation and angiogenesis

[64]

Down

c-Jun

Regulator of proliferation

[19]

Down

NA

NA

[29]