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Table 1 miR-125b associated with oncogenic signaling in cancer

From: Good guy or bad guy: the opposing roles of microRNA 125b in cancer

Tumor type Direction of misregulation miR-125b targets Comments Ref.
Hematopoetic tumors Up BCL2 Regulator of apoptosis [26]
  Up CBFβ Counteracts myeloid cell differentiation [27]
  Up Trp53inp1 Regulator of apoptosis [43]
  Up NA NA [25]
Colon cancer Up in colon cancer with poor prognosis p53 Prognostic indicator for colorectal cancer [38]
Non-small-cell lung cancer (NSCLC) Up in serum from patients with poor prognosis NA Prognostic serum marker for NSCLC [44]
Follicular cancer Up NA NA [29]
Gastric tumors Up NA Pro-proliferative, anti-apoptotic [28]
Pancreatic cancer Up NA NA [30]
  1. NA: not analyzed.