Signaling by epithelial members of the CEACAM family – mucosal docking sites for pathogenic bacteria

Table 1 CEACAM-binding bacteria and their adhesive proteins

Bacterial species	Primary target tissue	Adhesin	CEACAM specificity				References
Bacterial species	Primary target tissue	Adhesin	1	3	5	6	References
Adherent-invasive *Escherichia coli* (AIEC)	Digestive tract	FimH	-	NC	-	+	[68]
Diffusely adhering *Escherichia coli* (DAEC)	Digestive tract Urogenital tract	Afa/Dr-I	+	-	+	+	[69]
*Haemophilus influenzae*	Nasopharynx	OmpP5	+	NC	+	NC	[55, 70]
*Moraxella catarrhalis*	Nasopharynx	UspA1	+	+	+	NC	[56, 71]
*Neisseria gonorrhoeae*	Urogenital tract	Opa_CEA	+	+	+	+	[54, 72]
*Neisseria meningitidis*	Nasopharynx	Opa_CEA	+	+	+	+	[53]
commensal *Neisseria*	Nasopharynx	Opa_CEA	+	NC	NC	NC	[73]
*Salmonella sp*	Digestive tract	Uncharacterized fimbrial adhesin	+	NC	+	+	[51]

ISSN: 1478-811X